19 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBL3	Ubiquitin-like protein. (117 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (768 aa)
	CALML4	Uncharacterized protein. (153 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
	CALML3	Calmodulin, striated muscle; Belongs to the calmodulin family. (149 aa)
	VHL	Uncharacterized protein. (161 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
	CALM2	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (151 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	RPL11	Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. (178 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). (535 aa)
	CUL2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (442 aa)
	MLF1	Uncharacterized protein. (290 aa)
	SMAD7	Mothers against decapentaplegic homolog. (388 aa)
	CACUL1	Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
	TCEB1	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
	NEDD8	NEDD8 ubiquitin like modifier. (85 aa)
	NPM1	Nucleophosmin; Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single- stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity). Belongs to the nucleoplasmin family. (404 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CALM2	ENSGALP00000044604	ENSGALP00000046870	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.675
ALB	CALML3	ENSGALP00000044604	ENSGALP00000039444	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Calmodulin, striated muscle; Belongs to the calmodulin family.	0.656
ALB	CALML4	ENSGALP00000044604	ENSGALP00000012941	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Uncharacterized protein.	0.629
CACUL1	NEDD8	ENSGALP00000055119	ENSGALP00000055513	Cullin domain-containing protein; Belongs to the cullin family.	NEDD8 ubiquitin like modifier.	0.776
CACUL1	TCEB1	ENSGALP00000055119	ENSGALP00000055188	Cullin domain-containing protein; Belongs to the cullin family.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.487
CACUL1	UBA3	ENSGALP00000055119	ENSGALP00000052128	Cullin domain-containing protein; Belongs to the cullin family.	Ubiquitin like modifier activating enzyme 3.	0.415
CALM2	ALB	ENSGALP00000046870	ENSGALP00000044604	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	0.675
CALM2	CALML3	ENSGALP00000046870	ENSGALP00000039444	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Calmodulin, striated muscle; Belongs to the calmodulin family.	0.935
CALM2	CALML4	ENSGALP00000046870	ENSGALP00000012941	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein.	0.939
CALML3	ALB	ENSGALP00000039444	ENSGALP00000044604	Calmodulin, striated muscle; Belongs to the calmodulin family.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	0.656
CALML3	CALM2	ENSGALP00000039444	ENSGALP00000046870	Calmodulin, striated muscle; Belongs to the calmodulin family.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.935
CALML3	CALML4	ENSGALP00000039444	ENSGALP00000012941	Calmodulin, striated muscle; Belongs to the calmodulin family.	Uncharacterized protein.	0.903
CALML4	ALB	ENSGALP00000012941	ENSGALP00000044604	Uncharacterized protein.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	0.629
CALML4	CALM2	ENSGALP00000012941	ENSGALP00000046870	Uncharacterized protein.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.939
CALML4	CALML3	ENSGALP00000012941	ENSGALP00000039444	Uncharacterized protein.	Calmodulin, striated muscle; Belongs to the calmodulin family.	0.903
CUL1	CUL2	ENSGALP00000046909	ENSGALP00000050746	Cullin 1; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.719
CUL1	CUL3	ENSGALP00000046909	ENSGALP00000008177	Cullin 1; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.755
CUL1	MDM2	ENSGALP00000046909	ENSGALP00000016144	Cullin 1; Belongs to the cullin family.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.479
CUL1	NAE1	ENSGALP00000046909	ENSGALP00000050474	Cullin 1; Belongs to the cullin family.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity).	0.884
CUL1	NEDD8	ENSGALP00000046909	ENSGALP00000055513	Cullin 1; Belongs to the cullin family.	NEDD8 ubiquitin like modifier.	0.998