22 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	SHH	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
	SPRY2	Protein sprouty homolog 2; May play an important role in FGF-mediated patterning of the mid/hindbrain region by acting to modulate the signaling effects of FGF8 through participation in a regulatory negative feedback loop. (313 aa)
	FGF8	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1276 aa)
	PTF1A	Pancreas associated transcription factor 1a. (275 aa)
	EGF	Uncharacterized protein. (1283 aa)
	PAX2	Paired-box containing protein Pax-2. (394 aa)
	OTX2	Homeodomain transcription factor. (289 aa)
	EN2	Homeobox protein engrailed-2. (289 aa)
	OLIG2	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
	ASCL1	BHLH domain-containing protein. (219 aa)
	GBX2	Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa)
	EN1	Homeobox protein engrailed-1. (334 aa)
	LMX1B	LIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development. (400 aa)
	CALB1	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa)
	NEUROG1	Neurogenin 1. (179 aa)
	HNF1A	Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator. Belongs to the HNF1 homeobox family. (634 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (388 aa)
	PAX6	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
	WNT1	Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. Developmental protein that promotes cell proliferation in the developing spinal cord. Has a role in osteoblast function, bone development and bone homeostasis (By similarity). (550 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa)
	GDF10	Growth differentiation factor 10. (283 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	CALB1	ENSGALP00000047577	ENSGALP00000056213	BHLH domain-containing protein.	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	0.586
ASCL1	EGF	ENSGALP00000047577	ENSGALP00000044972	BHLH domain-containing protein.	Uncharacterized protein.	0.533
ASCL1	EN1	ENSGALP00000047577	ENSGALP00000052689	BHLH domain-containing protein.	Homeobox protein engrailed-1.	0.586
ASCL1	FGF8	ENSGALP00000047577	ENSGALP00000032574	BHLH domain-containing protein.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.532
ASCL1	LMX1B	ENSGALP00000047577	ENSGALP00000054070	BHLH domain-containing protein.	LIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development.	0.653
ASCL1	NEUROG1	ENSGALP00000047577	ENSGALP00000057908	BHLH domain-containing protein.	Neurogenin 1.	0.872
ASCL1	OLIG2	ENSGALP00000047577	ENSGALP00000047462	BHLH domain-containing protein.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.857
ASCL1	OTX2	ENSGALP00000047577	ENSGALP00000045234	BHLH domain-containing protein.	Homeodomain transcription factor.	0.712
ASCL1	PAX2	ENSGALP00000047577	ENSGALP00000045193	BHLH domain-containing protein.	Paired-box containing protein Pax-2.	0.553
ASCL1	PAX6	ENSGALP00000047577	ENSGALP00000070449	BHLH domain-containing protein.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.854
ASCL1	SHH	ENSGALP00000047577	ENSGALP00000010292	BHLH domain-containing protein.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.716
CALB1	ASCL1	ENSGALP00000056213	ENSGALP00000047577	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	BHLH domain-containing protein.	0.586
CALB1	EN1	ENSGALP00000056213	ENSGALP00000052689	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	Homeobox protein engrailed-1.	0.463
CALB1	FGF8	ENSGALP00000056213	ENSGALP00000032574	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.416
CALB1	OLIG2	ENSGALP00000056213	ENSGALP00000047462	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.603
CALB1	OTX2	ENSGALP00000056213	ENSGALP00000045234	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	Homeodomain transcription factor.	0.503
CALB1	PAX2	ENSGALP00000056213	ENSGALP00000045193	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	Paired-box containing protein Pax-2.	0.596
CALB1	PAX6	ENSGALP00000056213	ENSGALP00000070449	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.771
CALB1	PTF1A	ENSGALP00000056213	ENSGALP00000041335	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	Pancreas associated transcription factor 1a.	0.548
CALB1	SHH	ENSGALP00000056213	ENSGALP00000010292	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.510