23 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PINK1	PTEN induced kinase 1. (364 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (662 aa)
	UBE2T	Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (234 aa)
	CDC34	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (235 aa)
	RBX1	RING-type domain-containing protein. (108 aa)
	CAND1	Cullin associated and neddylation dissociated 1. (1230 aa)
	ENTPD8L	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (416 aa)
	LOC427778	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (497 aa)
	ENTPD8	Ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside ATPases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Belongs to the GDA1/CD39 NTPase family. (493 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
	SHARPIN	SHANK associated RH domain interactor. (481 aa)
	UBXN7	UBX domain protein 7. (623 aa)
	UBE2F	NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. (272 aa)
	ENTPD1	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (525 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	ENTPD3	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (511 aa)
	TCEB1	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
	CACUL1	Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (442 aa)
	CUL2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). (535 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (883 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACUL1	CAND1	ENSGALP00000055119	ENSGALP00000016080	Cullin domain-containing protein; Belongs to the cullin family.	Cullin associated and neddylation dissociated 1.	0.660
CACUL1	CDC34	ENSGALP00000055119	ENSGALP00000040341	Cullin domain-containing protein; Belongs to the cullin family.	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	0.497
CACUL1	CUL5	ENSGALP00000055119	ENSGALP00000045443	Cullin domain-containing protein; Belongs to the cullin family.	Cullin 5; Belongs to the cullin family.	0.402
CACUL1	RBX1	ENSGALP00000055119	ENSGALP00000019539	Cullin domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.709
CACUL1	TCEB1	ENSGALP00000055119	ENSGALP00000055188	Cullin domain-containing protein; Belongs to the cullin family.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.487
CACUL1	UBA3	ENSGALP00000055119	ENSGALP00000052128	Cullin domain-containing protein; Belongs to the cullin family.	Ubiquitin like modifier activating enzyme 3.	0.415
CACUL1	UBE2F	ENSGALP00000055119	ENSGALP00000064619	Cullin domain-containing protein; Belongs to the cullin family.	NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.	0.626
CACUL1	UBE2M	ENSGALP00000055119	ENSGALP00000057777	Cullin domain-containing protein; Belongs to the cullin family.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.615
CACUL1	UBXN7	ENSGALP00000055119	ENSGALP00000067842	Cullin domain-containing protein; Belongs to the cullin family.	UBX domain protein 7.	0.736
CAND1	CACUL1	ENSGALP00000016080	ENSGALP00000055119	Cullin associated and neddylation dissociated 1.	Cullin domain-containing protein; Belongs to the cullin family.	0.660
CAND1	CUL1	ENSGALP00000016080	ENSGALP00000046909	Cullin associated and neddylation dissociated 1.	Cullin 1; Belongs to the cullin family.	0.994
CAND1	CUL2	ENSGALP00000016080	ENSGALP00000050746	Cullin associated and neddylation dissociated 1.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.903
CAND1	CUL4B	ENSGALP00000016080	ENSGALP00000048714	Cullin associated and neddylation dissociated 1.	Cullin 4B; Belongs to the cullin family.	0.883
CAND1	CUL5	ENSGALP00000016080	ENSGALP00000045443	Cullin associated and neddylation dissociated 1.	Cullin 5; Belongs to the cullin family.	0.891
CAND1	NAE1	ENSGALP00000016080	ENSGALP00000050474	Cullin associated and neddylation dissociated 1.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity).	0.635
CAND1	RBX1	ENSGALP00000016080	ENSGALP00000019539	Cullin associated and neddylation dissociated 1.	RING-type domain-containing protein.	0.954
CAND1	TCEB1	ENSGALP00000016080	ENSGALP00000055188	Cullin associated and neddylation dissociated 1.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.845
CAND1	UBA3	ENSGALP00000016080	ENSGALP00000052128	Cullin associated and neddylation dissociated 1.	Ubiquitin like modifier activating enzyme 3.	0.663
CAND1	UBE2F	ENSGALP00000016080	ENSGALP00000064619	Cullin associated and neddylation dissociated 1.	NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.	0.704
CAND1	UBE2M	ENSGALP00000016080	ENSGALP00000057777	Cullin associated and neddylation dissociated 1.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.839