(17 nodes) (2013) Effects of reticuloendotheliosis virus infection on cytokine production in SPF chickens. network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	IL4	Interleukin 4. (136 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	CSF1	Uncharacterized protein. (493 aa)
	CD4	Uncharacterized protein. (487 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
	IFNA3	Interferon. (193 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	IL13	Interleukin-13. (138 aa)
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	IL2	Interleukin; Belongs to the IL-15/IL-21 family. (143 aa)
	IL17F	Uncharacterized protein. (169 aa)
	IL17A	Uncharacterized protein. (169 aa)
	IFNW1	Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family. (203 aa)
	IL3	Uncharacterized protein. (138 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD8A-2	ENSGALP00000065611	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.984
CD4	CD8A-3	ENSGALP00000065611	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.982
CD4	CSF1	ENSGALP00000065611	ENSGALP00000064854	Uncharacterized protein.	Uncharacterized protein.	0.470
CD4	GAPDH	ENSGALP00000065611	ENSGALP00000063325	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.761
CD4	IFNA3	ENSGALP00000065611	ENSGALP00000070204	Uncharacterized protein.	Interferon.	0.955
CD4	IFNW1	ENSGALP00000065611	ENSGALP00000038687	Uncharacterized protein.	Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family.	0.613
CD4	IL10	ENSGALP00000065611	ENSGALP00000001310	Uncharacterized protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.982
CD4	IL13	ENSGALP00000065611	ENSGALP00000010986	Uncharacterized protein.	Interleukin-13.	0.761
CD4	IL15	ENSGALP00000065611	ENSGALP00000069101	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.908
CD4	IL17A	ENSGALP00000065611	ENSGALP00000026862	Uncharacterized protein.	Uncharacterized protein.	0.981
CD4	IL17F	ENSGALP00000065611	ENSGALP00000026861	Uncharacterized protein.	Uncharacterized protein.	0.651
CD4	IL18	ENSGALP00000065611	ENSGALP00000012772	Uncharacterized protein.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.856
CD4	IL1B	ENSGALP00000065611	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.957
CD4	IL2	ENSGALP00000065611	ENSGALP00000019308	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.974
CD4	IL4	ENSGALP00000065611	ENSGALP00000039130	Uncharacterized protein.	Interleukin 4.	0.979
CD8A-2	CD4	ENSGALP00000059832	ENSGALP00000065611	Ig-like domain-containing protein.	Uncharacterized protein.	0.984
CD8A-2	CSF1	ENSGALP00000059832	ENSGALP00000064854	Ig-like domain-containing protein.	Uncharacterized protein.	0.440
CD8A-2	GAPDH	ENSGALP00000059832	ENSGALP00000063325	Ig-like domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.709
CD8A-2	IFNA3	ENSGALP00000059832	ENSGALP00000070204	Ig-like domain-containing protein.	Interferon.	0.959
CD8A-2	IFNW1	ENSGALP00000059832	ENSGALP00000038687	Ig-like domain-containing protein.	Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family.	0.701