STRINGSTRING
FANCG FANCG APTX APTX CLSPN CLSPN FANCE FANCE BRCA1 BRCA1 E2F1 E2F1 PMS2 PMS2 PTEN PTEN FANCF FANCF FANCD2 FANCD2 FANCI FANCI EME1 EME1 CDK6 CDK6 EXO1 EXO1 FANCC FANCC BCL2 BCL2 FOXM1 FOXM1 REV3L REV3L RAD23B RAD23B MSH3 MSH3 POLN POLN TXN TXN FANCB FANCB LIG4 LIG4 BRCA2 BRCA2 DNTT DNTT UNG UNG RAD54L RAD54L PARP1 PARP1 MSH6 MSH6 RAD50 RAD50 XPA XPA TOP1 TOP1 RAD9A RAD9A MLH1 MLH1 RAD51C RAD51C SLX4 SLX4 RAD51D RAD51D RAD54B RAD54B XRCC6 XRCC6 FANCL FANCL HUS1 HUS1 SMC3 SMC3 CDK2 CDK2 CDC25A CDC25A MGMT MGMT PRKDC PRKDC XRCC3 XRCC3 RAD52 RAD52 PCNA PCNA APLF APLF TDP1 TDP1 WRN WRN RAD51B RAD51B FANCM FANCM FAN1 FAN1 PNKP PNKP TOP1MT TOP1MT RAD17 RAD17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FANCGUncharacterized protein. (648 aa)
APTXAprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'- monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), b [...] (350 aa)
CLSPNUncharacterized protein. (1337 aa)
FANCEFA_FANCE domain-containing protein. (244 aa)
BRCA1Uncharacterized protein. (1749 aa)
E2F1Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa)
PMS2Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (869 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (423 aa)
FANCFFA complementation group F. (391 aa)
FANCD2Uncharacterized protein. (1510 aa)
FANCIUncharacterized protein. (1339 aa)
EME1Essential meiotic structure-specific endonuclease 1. (568 aa)
CDK6Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa)
EXO1Uncharacterized protein. (800 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
FOXM1Fork-head domain-containing protein. (795 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3167 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (504 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1090 aa)
POLNPOLAc domain-containing protein. (307 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
FANCBUncharacterized protein. (965 aa)
LIG4DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. (912 aa)
BRCA2Tower domain-containing protein. (3397 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. (506 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (299 aa)
RAD54LDNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (804 aa)
PARP1Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...] (1011 aa)
MSH6DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (1342 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
XPADNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. (270 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (747 aa)
RAD9ARad9. (376 aa)
MLH1DNA mismatch repair protein MLH1. (757 aa)
RAD51CRAD51 paralog C. (360 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1740 aa)
RAD51DRECA_2 domain-containing protein. (327 aa)
RAD54BDNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (918 aa)
XRCC6X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (647 aa)
FANCLFanconi anemia protein FANCL. (373 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (284 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CDC25ARhodanese domain-containing protein. (526 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (260 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...] (4132 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa)
RAD52DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). (422 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
APLFUncharacterized protein. (531 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (617 aa)
WRNUncharacterized protein. (1622 aa)
RAD51BRAD51 paralog B. (415 aa)
FANCMFanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1034 aa)
PNKPUncharacterized protein. (206 aa)
TOP1MTDNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (753 aa)
RAD17Uncharacterized protein. (735 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.