STRINGSTRING
E2F6 E2F6 HIST1H3H HIST1H3H DMB2 DMB2 WDR61 WDR61 SPO11 SPO11 TOP2A TOP2A TOP2B TOP2B ENSGALP00000055994 ENSGALP00000055994 BRCA1 BRCA1 DNA2 DNA2 HISTH1 HISTH1 ATM ATM H3F3C H3F3C RAD50 RAD50 ENSGALP00000069661 ENSGALP00000069661
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E2F6E2F_TDP domain-containing protein. (252 aa)
HIST1H3HHistone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
DMB2Ig-like domain-containing protein. (323 aa)
WDR61WD repeat-containing protein 61. (326 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (382 aa)
TOP2ADNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in the regulation of circadian rhythm. (1553 aa)
TOP2BDNA topoisomerase 2-beta; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks; Belongs to the type II topoisomerase family. (1628 aa)
ENSGALP00000055994Histone H3; Belongs to the histone H3 family. (136 aa)
BRCA1Uncharacterized protein. (1749 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...] (992 aa)
HISTH1Histone H1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (305 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
H3F3CHistone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
ENSGALP00000069661Histone H3; Belongs to the histone H3 family. (98 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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