STRINGSTRING
REL REL EOMES EOMES FOXP1 FOXP1 BCL2L1 BCL2L1 CD8A-2 CD8A-2 CD8A-3 CD8A-3 CD44 CD44 CD4 CD4 PDCD1 PDCD1 TRAF1 TRAF1 BCL2 BCL2 OVAL OVAL CD40 CD40
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELProto-oncogene c-Rel; Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferen [...] (598 aa)
EOMEST-box_assoc domain-containing protein. (661 aa)
FOXP1Forkhead box protein P1; Transcriptional repressor. (686 aa)
BCL2L1Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
CD44Link domain-containing protein. (696 aa)
CD4Uncharacterized protein. (487 aa)
PDCD1Ig-like domain-containing protein. (304 aa)
TRAF1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
CD40Uncharacterized protein. (299 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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