(20 nodes) (2013) Oncolytic Newcastle Disease Virus as Cutting Edge between Tumor and Host. network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	CCR7	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	IFIH1	Uncharacterized protein. (1102 aa)
	STAT1	Signal transducer and activator of transcription. (755 aa)
	IL4	Interleukin 4. (136 aa)
	IRF7	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	EIF2AK2	Uncharacterized protein. (550 aa)
	FURIN	Trans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)
	STAT4	Signal transducer and activator of transcription. (749 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	IFNA3	Interferon. (193 aa)
	CD36	Uncharacterized protein; Belongs to the CD36 family. (471 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	CD4	Uncharacterized protein. (487 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	LGALS3	Galectin. (258 aa)
	STAT5A	Signal transducer and activator of transcription. (764 aa)
	STAT2	Signal transducer and activator of transcription. (961 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR7	CD4	ENSGALP00000048400	ENSGALP00000065611	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.908
CCR7	CD8A-2	ENSGALP00000048400	ENSGALP00000059832	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Ig-like domain-containing protein.	0.879
CCR7	CD8A-3	ENSGALP00000048400	ENSGALP00000071819	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Ig-like domain-containing protein.	0.879
CCR7	IFNA3	ENSGALP00000048400	ENSGALP00000070204	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interferon.	0.514
CCR7	IL10	ENSGALP00000048400	ENSGALP00000001310	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.745
CCR7	IL1B	ENSGALP00000048400	ENSGALP00000050171	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-1; Belongs to the IL-1 family.	0.660
CCR7	IL4	ENSGALP00000048400	ENSGALP00000039130	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin 4.	0.705
CCR7	IL6	ENSGALP00000048400	ENSGALP00000068117	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.752
CCR7	LGALS3	ENSGALP00000048400	ENSGALP00000055146	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Galectin.	0.480
CCR7	STAT1	ENSGALP00000048400	ENSGALP00000046362	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Signal transducer and activator of transcription.	0.418
CCR7	TLR3	ENSGALP00000048400	ENSGALP00000021914	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.435
CD36	CD4	ENSGALP00000068876	ENSGALP00000065611	Uncharacterized protein; Belongs to the CD36 family.	Uncharacterized protein.	0.536
CD36	CD8A-2	ENSGALP00000068876	ENSGALP00000059832	Uncharacterized protein; Belongs to the CD36 family.	Ig-like domain-containing protein.	0.493
CD36	CD8A-3	ENSGALP00000068876	ENSGALP00000071819	Uncharacterized protein; Belongs to the CD36 family.	Ig-like domain-containing protein.	0.489
CD36	IL10	ENSGALP00000068876	ENSGALP00000001310	Uncharacterized protein; Belongs to the CD36 family.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.584
CD36	IL1B	ENSGALP00000068876	ENSGALP00000050171	Uncharacterized protein; Belongs to the CD36 family.	Interleukin-1; Belongs to the IL-1 family.	0.602
CD36	IL4	ENSGALP00000068876	ENSGALP00000039130	Uncharacterized protein; Belongs to the CD36 family.	Interleukin 4.	0.422
CD36	IL6	ENSGALP00000068876	ENSGALP00000068117	Uncharacterized protein; Belongs to the CD36 family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.652
CD36	LGALS3	ENSGALP00000068876	ENSGALP00000055146	Uncharacterized protein; Belongs to the CD36 family.	Galectin.	0.457
CD4	CCR7	ENSGALP00000065611	ENSGALP00000048400	Uncharacterized protein.	C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.908