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CACUL1 | Cullin domain-containing protein; Belongs to the cullin family. (377 aa) | ||||
CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) | ||||
OTX2 | Homeodomain transcription factor. (289 aa) | ||||
EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (631 aa) | ||||
EYA1 | Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa) |