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KCNMA1 KCNMA1 ADCYAP1 ADCYAP1 RGS10 RGS10 SHOX2 SHOX2 CALB1 CALB1 CALCA CALCA SLC17A8 SLC17A8 TRPA1 TRPA1 GRIA1 GRIA1 HPCAL1 HPCAL1 GRIK1 GRIK1 CNTF CNTF DBH DBH SCG2 SCG2 PVALB PVALB GAL GAL CALB2 CALB2 GALR1 GALR1 NTS NTS SSTR2 SSTR2 HBBA HBBA NT5E NT5E TRPC3 TRPC3 KITLG KITLG BDKRB2 BDKRB2 NPY NPY SPP1 SPP1 NPY1R NPY1R GFRA1 GFRA1 LPAR3 LPAR3 KCNIP2 KCNIP2 GFRA3 GFRA3 RGS4 RGS4 SST SST TRPV1 TRPV1 TRPM8 TRPM8 TRPM1 TRPM1 GDNF GDNF HPCA HPCA GALR1L GALR1L MOXD1 MOXD1 BDNF BDNF NRTN NRTN NTF3 NTF3 NTRK2 NTRK2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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KCNMA1Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] (1247 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide 27; Primary role of GRF is to release GH from the pituitary; Belongs to the glucagon family. (172 aa)
RGS10Regulator of G protein signaling 10. (181 aa)
SHOX2Short stature homeobox 2. (316 aa)
CALB1Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa)
CALCACalcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. (138 aa)
SLC17A8MFS domain-containing protein. (587 aa)
TRPA1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1126 aa)
GRIA1Uncharacterized protein. (902 aa)
HPCAL1Hippocalcin-like protein 1. (227 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (926 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (195 aa)
DBHDopamine beta-hydroxylase. (584 aa)
SCG2Secretogranin II. (629 aa)
PVALBParvalbumin, muscle; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity); Belongs to the parvalbumin family. (134 aa)
GALGalanin variant 1. (141 aa)
CALB2Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa)
GALR1Galanin receptor; Belongs to the G-protein coupled receptor 1 family. (357 aa)
NTSNeurotensin. (164 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (371 aa)
HBBAHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (561 aa)
TRPC3ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (933 aa)
KITLGProcessed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa)
BDKRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (264 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (385 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). (469 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa)
KCNIP2Uncharacterized protein. (295 aa)
GFRA3GDNF family receptor alpha 3. (422 aa)
RGS4Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity). (209 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
TRPV1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (843 aa)
TRPM8Uncharacterized protein. (1095 aa)
TRPM1Transient receptor potential cation channel subfamily M member 1. (1625 aa)
GDNFGlial cell derived neurotrophic factor. (209 aa)
HPCAHippocalcin. (193 aa)
GALR1LG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
MOXD1DBH-like monooxygenase protein 1. (614 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa)
NRTNTGF_BETA_2 domain-containing protein. (257 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons. (270 aa)
NTRK2BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] (842 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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