(5 nodes) (2015) Deoxynivalenol induces apoptosis in chicken splenic lymphocytes via the reactive oxygen species-mediated mitochondrial pathway. network (Gallus gallus)

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Your Input:
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	CCK	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa)
	ANXA5	Annexin A5; Collagen-binding protein. (321 aa)
	BAK1	Uncharacterized protein. (216 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA5	BCL2	ENSGALP00000055261	ENSGALP00000020984	Annexin A5; Collagen-binding protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.876
ANXA5	CASP3	ENSGALP00000055261	ENSGALP00000068843	Annexin A5; Collagen-binding protein.	Caspase-3; Belongs to the peptidase C14A family.	0.960
ANXA5	CCK	ENSGALP00000055261	ENSGALP00000044506	Annexin A5; Collagen-binding protein.	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	0.827
BAK1	BCL2	ENSGALP00000055311	ENSGALP00000020984	Uncharacterized protein.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.985
BAK1	CASP3	ENSGALP00000055311	ENSGALP00000068843	Uncharacterized protein.	Caspase-3; Belongs to the peptidase C14A family.	0.751
BCL2	ANXA5	ENSGALP00000020984	ENSGALP00000055261	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Annexin A5; Collagen-binding protein.	0.876
BCL2	BAK1	ENSGALP00000020984	ENSGALP00000055311	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.985
BCL2	CASP3	ENSGALP00000020984	ENSGALP00000068843	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase-3; Belongs to the peptidase C14A family.	0.989
BCL2	CCK	ENSGALP00000020984	ENSGALP00000044506	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	0.698
CASP3	ANXA5	ENSGALP00000068843	ENSGALP00000055261	Caspase-3; Belongs to the peptidase C14A family.	Annexin A5; Collagen-binding protein.	0.960
CASP3	BAK1	ENSGALP00000068843	ENSGALP00000055311	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.751
CASP3	BCL2	ENSGALP00000068843	ENSGALP00000020984	Caspase-3; Belongs to the peptidase C14A family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.989
CASP3	CCK	ENSGALP00000068843	ENSGALP00000044506	Caspase-3; Belongs to the peptidase C14A family.	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	0.766
CCK	ANXA5	ENSGALP00000044506	ENSGALP00000055261	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Annexin A5; Collagen-binding protein.	0.827
CCK	BCL2	ENSGALP00000044506	ENSGALP00000020984	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.698
CCK	CASP3	ENSGALP00000044506	ENSGALP00000068843	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Caspase-3; Belongs to the peptidase C14A family.	0.766