(9 nodes) (2015) BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCNA1	Cyclin A1; Belongs to the cyclin family. (406 aa)
	PXDN	Peroxidasin. (1611 aa)
	CCNA2	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa)
	EXO1	Uncharacterized protein. (800 aa)
	PXDNL	Uncharacterized protein. (1406 aa)
	RAD51	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa)
	RAD50	Zinc-hook domain-containing protein. (1313 aa)
	RAD54L	DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (804 aa)
	BRCA2	Tower domain-containing protein. (3397 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	CCNA1	ENSGALP00000027524	ENSGALP00000027497	Tower domain-containing protein.	Cyclin A1; Belongs to the cyclin family.	0.514
BRCA2	CCNA2	ENSGALP00000027524	ENSGALP00000019361	Tower domain-containing protein.	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	0.587
BRCA2	EXO1	ENSGALP00000027524	ENSGALP00000017465	Tower domain-containing protein.	Uncharacterized protein.	0.967
BRCA2	RAD50	ENSGALP00000027524	ENSGALP00000039135	Tower domain-containing protein.	Zinc-hook domain-containing protein.	0.608
BRCA2	RAD51	ENSGALP00000027524	ENSGALP00000046453	Tower domain-containing protein.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.	0.999
BRCA2	RAD54L	ENSGALP00000027524	ENSGALP00000037559	Tower domain-containing protein.	DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family.	0.964
CCNA1	BRCA2	ENSGALP00000027497	ENSGALP00000027524	Cyclin A1; Belongs to the cyclin family.	Tower domain-containing protein.	0.514
CCNA1	CCNA2	ENSGALP00000027497	ENSGALP00000019361	Cyclin A1; Belongs to the cyclin family.	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	0.936
CCNA1	EXO1	ENSGALP00000027497	ENSGALP00000017465	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.638
CCNA1	PXDN	ENSGALP00000027497	ENSGALP00000026363	Cyclin A1; Belongs to the cyclin family.	Peroxidasin.	0.460
CCNA1	PXDNL	ENSGALP00000027497	ENSGALP00000049777	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.459
CCNA1	RAD50	ENSGALP00000027497	ENSGALP00000039135	Cyclin A1; Belongs to the cyclin family.	Zinc-hook domain-containing protein.	0.507
CCNA1	RAD51	ENSGALP00000027497	ENSGALP00000046453	Cyclin A1; Belongs to the cyclin family.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.	0.480
CCNA2	BRCA2	ENSGALP00000019361	ENSGALP00000027524	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Tower domain-containing protein.	0.587
CCNA2	CCNA1	ENSGALP00000019361	ENSGALP00000027497	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Cyclin A1; Belongs to the cyclin family.	0.936
CCNA2	EXO1	ENSGALP00000019361	ENSGALP00000017465	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Uncharacterized protein.	0.716
CCNA2	PXDN	ENSGALP00000019361	ENSGALP00000026363	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Peroxidasin.	0.503
CCNA2	PXDNL	ENSGALP00000019361	ENSGALP00000049777	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Uncharacterized protein.	0.503
CCNA2	RAD50	ENSGALP00000019361	ENSGALP00000039135	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	Zinc-hook domain-containing protein.	0.507
CCNA2	RAD51	ENSGALP00000019361	ENSGALP00000046453	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.	0.610