STRINGSTRING
POLDIP3 POLDIP3 GRM1 GRM1 RAB32 RAB32 ADGB ADGB FOXRED2 FOXRED2 RBFOX2 RBFOX2 MB MB RASD2 RASD2 MCM5 MCM5 TOM1 TOM1 EPM2A EPM2A HMOX1 HMOX1 RNASE6 RNASE6 CYGB CYGB PGAP6 PGAP6 SAMD5 SAMD5 MED29 MED29 SPHK1 SPHK1 GBX1 GBX1 HBA1 HBA1 HBAD HBAD MYH9 MYH9 NPRL3 NPRL3 TXN2 TXN2 HMGXB4 HMGXB4 TIMM50 TIMM50 STXBP5 STXBP5 LUC7L LUC7L METTL23 METTL23 JMJD6 JMJD6 PRPSAP1 PRPSAP1 RHBDF2 RHBDF2 AANAT AANAT HBZ HBZ NGB NGB GBE GBE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLDIP3RRM domain-containing protein. (418 aa)
GRM1Glutamate metabotropic receptor 1. (1152 aa)
RAB32Uncharacterized protein. (218 aa)
ADGBGLOBIN domain-containing protein; Belongs to the globin family. (440 aa)
FOXRED2FAD dependent oxidoreductase domain containing 2. (680 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (367 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
RASD2RASD family member 2. (266 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
TOM1Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes; Belongs to the TOM1 family. (515 aa)
EPM2ALaforin. (319 aa)
HMOX1Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. (317 aa)
RNASE6Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). (139 aa)
CYGBCytoglobin; Belongs to the globin family. (179 aa)
PGAP6Transmembrane protein 8A. (761 aa)
SAMD5Sterile alpha motif domain containing 5. (155 aa)
MED29Uncharacterized protein. (121 aa)
SPHK1Sphingosine kinase 1. (649 aa)
GBX1Gastrulation brain homeobox 1. (243 aa)
HBA1Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
HBADHemoglobin subunit alpha-D; Involved in oxygen transport from the lung to the various peripheral tissues. (141 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
TXN2Thioredoxin domain-containing protein. (150 aa)
HMGXB4Uncharacterized protein. (163 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (230 aa)
STXBP5Syntaxin binding protein 5. (1152 aa)
LUC7LLUC7 like. (332 aa)
METTL23Methyltransferase like 23. (230 aa)
JMJD6Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] (414 aa)
PRPSAP1Phosphoribosyl pyrophosphate synthetase associated protein 1. (383 aa)
RHBDF2Rhomboid 5 homolog 2. (861 aa)
AANATSerotonin N-acetyltransferase; Catalyzes the N-acetylation of serotonin into N- acetylserotonin; Belongs to the acetyltransferase family. AANAT subfamily. (205 aa)
HBZHemoglobin subunit pi; The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P; Belongs to the globin family. (142 aa)
NGBNeuroglobin; Belongs to the globin family. (160 aa)
GBEEye-globin; Belongs to the globin family. (151 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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