STRINGSTRING
GPX7 GPX7 TXN TXN AXIN1 AXIN1 SRXN1 SRXN1 RHEB RHEB RPTOR RPTOR ME1 ME1 PRKN PRKN RNF4 RNF4 FYN FYN DUSP6 DUSP6 GPX4 GPX4 PGAM5 PGAM5 CD36 CD36 HCK HCK FER FER BMX BMX PPARG PPARG NOX4 NOX4 MATK MATK TXNRD2 TXNRD2 NRARP NRARP SEC13 SEC13 TXNRD1 TXNRD1 WNT3A WNT3A TXN2 TXN2 CDK2 CDK2 KRAS KRAS CACUL1 CACUL1 CREBBP CREBBP DEPDC6 DEPDC6 SESN2 SESN2 TYK2 TYK2 PPARA PPARA ABL2 ABL2 MAFG MAFG RPS6KA1 RPS6KA1 TALDO1 TALDO1 IL1B IL1B PARK7 PARK7 CYP1B1 CYP1B1 SESN1 SESN1 INSR INSR RARA RARA AHR AHR LYN LYN GSR GSR CUL1 CUL1 RXRA RXRA FBXW11 FBXW11 EGF EGF ERBB2 ERBB2 ATF6 ATF6 KLF9 KLF9 GPX1 GPX1 GPX8 GPX8 CYP1A1 CYP1A1 BLK BLK GSTA2 GSTA2 GSTA3 GSTA3 HPGDS HPGDS PRKD3 PRKD3 SPP1 SPP1 JAK1 JAK1 SOD2 SOD2 HIF1A HIF1A RBX1 RBX1 MAFF MAFF CXCR4 CXCR4 BPGM BPGM CYBB CYBB AKR1B10 AKR1B10 FH FH PPAT PPAT TEC TEC FRK FRK AKR1A1 AKR1A1 PRKD1 PRKD1 CDK6 CDK6 PTPN1 PTPN1 CCND1 CCND1 SKP1 SKP1 MLST8 MLST8 SRMS SRMS XBP1 XBP1 DEPTOR DEPTOR SESN2-2 SESN2-2 TSC2 TSC2 TKT TKT CUL3 CUL3 IRS1 IRS1 LOC100859347 LOC100859347 CCNB1 CCNB1 AKR7L AKR7L ABL1 ABL1 SRC SRC RICTOR RICTOR PTEN PTEN MTOR MTOR BRCA1 BRCA1 SIRT1 SIRT1 NOTCH1 NOTCH1 ZAP70 ZAP70
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
AXIN1Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (841 aa)
SRXN1Sulfiredoxin. (155 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1374 aa)
ME1Malic enzyme. (655 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (488 aa)
RNF4RING-type domain-containing protein. (194 aa)
FYNTyrosine-protein kinase Fyn; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling. (589 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (388 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (352 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
HCKTyrosine-protein kinase. (514 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
BMXTyrosine-protein kinase. (630 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
NOX4FAD-binding FR-type domain-containing protein. (639 aa)
MATKTyrosine-protein kinase. (479 aa)
TXNRD2Uncharacterized protein. (515 aa)
NRARPNOTCH regulated ankyrin repeat protein. (124 aa)
SEC13WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family. (579 aa)
TXNRD1Uncharacterized protein. (530 aa)
WNT3AProtein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250|UniProtKB:P56704. (376 aa)
TXN2Thioredoxin domain-containing protein. (150 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
KRASUncharacterized protein. (189 aa)
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
CREBBPCREB binding protein. (2522 aa)
DEPDC6Uncharacterized protein. (397 aa)
SESN2Uncharacterized protein. (474 aa)
TYK2Tyrosine-protein kinase. (1212 aa)
PPARAUncharacterized protein. (468 aa)
ABL2Tyrosine-protein kinase. (1159 aa)
MAFGTranscription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. May be involved in signal transduction of extracellula [...] (162 aa)
RPS6KA1Ribosomal protein S6 kinase 2 alpha; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription. (760 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
PARK7Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] (189 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
SESN1Sestrin 1. (564 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
RARARetinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning and appears to be required for skin development. Belongs to the nuclear hormone receptor family. NR1 subfamily. (460 aa)
AHRUncharacterized protein. (877 aa)
LYNTyrosine-protein kinase. (491 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (464 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
RXRARetinoid X receptor alpha. (467 aa)
FBXW11Uncharacterized protein. (531 aa)
EGFUncharacterized protein. (1283 aa)
ERBB2Receptor protein-tyrosine kinase. (1200 aa)
ATF6Activating transcription factor 6. (671 aa)
KLF9Kruppel like factor 9. (235 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (182 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
CYP1A1Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
BLKTyrosine-protein kinase. (526 aa)
GSTA2Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
GSTA3Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (221 aa)
HPGDSHematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide. (199 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (264 aa)
JAK1Tyrosine-protein kinase. (1150 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
HIF1AHypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
RBX1RING-type domain-containing protein. (108 aa)
MAFFTranscription factor MafF; Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response; Belongs to the bZIP family. Maf subfamily. (149 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
BPGMPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
CYBBFAD-binding FR-type domain-containing protein. (570 aa)
AKR1B10Aldo-keto reductase. (317 aa)
FHUncharacterized protein. (507 aa)
PPATAmidophosphoribosyltransferase. (510 aa)
TECTyrosine-protein kinase. (630 aa)
FRKTyrosine-protein kinase. (533 aa)
AKR1A1Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Displays no reductase activity towards retinoids (By similarity). (365 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (899 aa)
CDK6Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type 1; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). (475 aa)
CCND1G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
SRMSTyrosine-protein kinase. (491 aa)
XBP1BZIP domain-containing protein. (372 aa)
DEPTORUncharacterized protein. (413 aa)
SESN2-2Uncharacterized protein. (450 aa)
TSC2TSC complex subunit 2. (1872 aa)
TKTTransketolase. (627 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
IRS1Insulin receptor substrate 1. (1178 aa)
LOC100859347Uncharacterized protein. (964 aa)
CCNB1G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (399 aa)
AKR7LAldo-keto reductase family 7 like (gene/pseudogene). (326 aa)
ABL1Tyrosine-protein kinase. (1111 aa)
SRCProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1711 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (423 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
BRCA1Uncharacterized protein. (1749 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (881 aa)
NOTCH1Uncharacterized protein. (2561 aa)
ZAP70Tyrosine-protein kinase. (609 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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