32 items (Gallus gallus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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gene fusions

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Your Input:
	FGFR3	Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (806 aa)
	LMX1A	Uncharacterized protein. (380 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	NEUROD1	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
	BMP4	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF8	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	FGF23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	PAX2	Paired-box containing protein Pax-2. (394 aa)
	SOX2	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
	SIX1	Sine oculis-related homeobox 1 homolog. (282 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
	ASCL1	BHLH domain-containing protein. (219 aa)
	POU4F3	POU domain protein. (326 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	EYA1	Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FOXG1	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	POU4F3-2	Brain-specific homeobox/POU domain protein 3; May play a role in specifying terminally differentiated neuronal phenotypes; Belongs to the POU transcription factor family. Class-4 subfamily. (341 aa)
	NEUROG1	Neurogenin 1. (179 aa)
	FGF10	Uncharacterized protein. (261 aa)
	ATOH7	Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3. (151 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (488 aa)
	GATA3	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	BMP4	ENSGALP00000047577	ENSGALP00000020289	BHLH domain-containing protein.	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	0.509
ASCL1	FGF10	ENSGALP00000047577	ENSGALP00000065453	BHLH domain-containing protein.	Uncharacterized protein.	0.406
ASCL1	FGF11	ENSGALP00000047577	ENSGALP00000073219	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
ASCL1	FGF12	ENSGALP00000047577	ENSGALP00000051076	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
ASCL1	FGF13	ENSGALP00000047577	ENSGALP00000054094	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.420
ASCL1	FGF14	ENSGALP00000047577	ENSGALP00000027195	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF16	ENSGALP00000047577	ENSGALP00000012648	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
ASCL1	FGF18	ENSGALP00000047577	ENSGALP00000054695	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.433
ASCL1	FGF19	ENSGALP00000047577	ENSGALP00000043371	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.428
ASCL1	FGF20	ENSGALP00000047577	ENSGALP00000022184	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.422
ASCL1	FGF22	ENSGALP00000047577	ENSGALP00000046847	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF23	ENSGALP00000047577	ENSGALP00000042002	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF5	ENSGALP00000047577	ENSGALP00000065598	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.422
ASCL1	FGF6	ENSGALP00000047577	ENSGALP00000027889	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF7	ENSGALP00000047577	ENSGALP00000042868	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.408
ASCL1	FGF8	ENSGALP00000047577	ENSGALP00000032574	BHLH domain-containing protein.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.532
ASCL1	FGF9	ENSGALP00000047577	ENSGALP00000041598	BHLH domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.422
ASCL1	FOXG1	ENSGALP00000047577	ENSGALP00000054672	BHLH domain-containing protein.	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	0.650
ASCL1	GATA3	ENSGALP00000047577	ENSGALP00000068882	BHLH domain-containing protein.	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	0.626
ASCL1	HEY1	ENSGALP00000047577	ENSGALP00000068672	BHLH domain-containing protein.	Hes related family bHLH transcription factor with YRPW motif 1.	0.456