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CRYBB3 CRYBB3 E2F4 E2F4 LHX3 LHX3 MTOR MTOR SPARC SPARC WIPI2 WIPI2 PITX3 PITX3 CRYGN CRYGN CTSD CTSD APOA1 APOA1 SST SST AHSG AHSG NEUROD1 NEUROD1 BNIP3 BNIP3 CRYBA2 CRYBA2 HIF1A HIF1A TFAP2A TFAP2A GCG GCG HBBA HBBA ATF4 ATF4 JUN JUN CRYBB2 CRYBB2 MAF MAF FOXE3 FOXE3 FOXO6 FOXO6 OTX2 OTX2 SOX2 SOX2 CTNNB1 CTNNB1 TFEB TFEB PARK7 PARK7 HSPB2 HSPB2 COL4A1 COL4A1 HIST1H4B HIST1H4B HBA1 HBA1 SOX1 SOX1 HIST1H4B-2 HIST1H4B-2 SQSTM1 SQSTM1 WIPI1 WIPI1 HIST1H4B-3 HIST1H4B-3 MAFB MAFB FOXO1 FOXO1 HEY2 HEY2 CTCF CTCF HIST1H46 HIST1H46 CRYBA4 CRYBA4 HIST1H4B-4 HIST1H4B-4 MYCN MYCN HIST1H4B-5 HIST1H4B-5 HEY1 HEY1 GATA3 GATA3 CRYBB1 CRYBB1 FIS1 FIS1 LRRC4C LRRC4C PAX6 PAX6 CACNA2D1 CACNA2D1 HIST1H4B-6 HIST1H4B-6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRYBB3Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens. (211 aa)
E2F4E2F transcription factor 4. (414 aa)
LHX3LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
WIPI2WD repeat domain phosphoinositide-interacting protein 2; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. (436 aa)
PITX3Uncharacterized protein. (338 aa)
CRYGNUncharacterized protein; Belongs to the beta/gamma-crystallin family. (183 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
APOA1Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT); Belongs to the apolipoprotein A1/A4/E family. (264 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
AHSGAlpha 2-HS glycoprotein. (344 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
BNIP3BCL2 interacting protein 3. (155 aa)
CRYBA2Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens. (196 aa)
HIF1AHypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
TFAP2ATF_AP-2 domain-containing protein. (437 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
HBBAHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
ATF4ATF4. (354 aa)
JUNTranscription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (310 aa)
CRYBB2Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens. (205 aa)
MAFTranscription factor Maf; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). (369 aa)
FOXE3Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis. (386 aa)
FOXO6Forkhead box O6. (608 aa)
OTX2Homeodomain transcription factor. (289 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
CTNNB1Uncharacterized protein. (781 aa)
TFEBBHLH domain-containing protein. (493 aa)
PARK7Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] (189 aa)
HSPB2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (173 aa)
COL4A1Collagen IV NC1 domain-containing protein. (1669 aa)
HIST1H4BHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
HBA1Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
SOX1Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa)
HIST1H4B-2Histone cluster 1, H4d. (103 aa)
SQSTM1Sequestosome 1. (453 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (508 aa)
HIST1H4B-3Histone cluster 1, H4-IV, germinal H4-like 6 (similar to human histone cluster 1, class H4 genes). (103 aa)
MAFBTranscription factor MafB; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha-A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). (311 aa)
FOXO1Fork-head domain-containing protein. (727 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (335 aa)
CTCFTranscriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene. (739 aa)
HIST1H46Histone cluster 1, H4-VI, germinal H4 (similar to human histone cluster 1, class H4 genes). (103 aa)
CRYBA4Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens. (196 aa)
HIST1H4B-4Histone cluster 1, H4i. (103 aa)
MYCNN-myc proto-oncogene protein. (441 aa)
HIST1H4B-5Histone cluster 2, H4b. (103 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (488 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
CRYBB1Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens. (238 aa)
FIS1Fission, mitochondrial 1. (155 aa)
LRRC4CLeucine rich repeat containing 4C. (638 aa)
PAX6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
CACNA2D1VWFA domain-containing protein. (1155 aa)
HIST1H4B-6Histone cluster 1, H4-IV, germinal H4-like 2. (103 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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