8 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC18A3	MFS domain-containing protein. (522 aa)
	PPY	Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. (80 aa)
	GALR1	Galanin receptor; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	SST	Somatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	GALR1L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	MNX1	Homeobox domain-containing protein. (348 aa)
	TH	Tyrosine hydroxylase. (491 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GALR1	SST	ENSGALP00000041025	ENSGALP00000011889	Galanin receptor; Belongs to the G-protein coupled receptor 1 family.	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	0.738
INS	MNX1	ENSGALP00000010567	ENSGALP00000056537	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Homeobox domain-containing protein.	0.499
INS	PPY	ENSGALP00000010567	ENSGALP00000043946	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family.	0.879
INS	SST	ENSGALP00000010567	ENSGALP00000011889	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	0.943
INS	TH	ENSGALP00000010567	ENSGALP00000051175	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Tyrosine hydroxylase.	0.583
MNX1	INS	ENSGALP00000056537	ENSGALP00000010567	Homeobox domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.499
MNX1	PPY	ENSGALP00000056537	ENSGALP00000043946	Homeobox domain-containing protein.	Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family.	0.483
MNX1	SLC18A3	ENSGALP00000056537	ENSGALP00000045682	Homeobox domain-containing protein.	MFS domain-containing protein.	0.678
PPY	INS	ENSGALP00000043946	ENSGALP00000010567	Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.879
PPY	MNX1	ENSGALP00000043946	ENSGALP00000056537	Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family.	Homeobox domain-containing protein.	0.483
PPY	SST	ENSGALP00000043946	ENSGALP00000011889	Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family.	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	0.960
SLC18A3	MNX1	ENSGALP00000045682	ENSGALP00000056537	MFS domain-containing protein.	Homeobox domain-containing protein.	0.678
SLC18A3	SST	ENSGALP00000045682	ENSGALP00000011889	MFS domain-containing protein.	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	0.499
SLC18A3	TH	ENSGALP00000045682	ENSGALP00000051175	MFS domain-containing protein.	Tyrosine hydroxylase.	0.815
SST	GALR1	ENSGALP00000011889	ENSGALP00000041025	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	Galanin receptor; Belongs to the G-protein coupled receptor 1 family.	0.738
SST	INS	ENSGALP00000011889	ENSGALP00000010567	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.943
SST	PPY	ENSGALP00000011889	ENSGALP00000043946	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family.	0.960
SST	SLC18A3	ENSGALP00000011889	ENSGALP00000045682	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	MFS domain-containing protein.	0.499
SST	TH	ENSGALP00000011889	ENSGALP00000051175	Somatostatin-14; Somatostatin inhibits the release of somatotropin.	Tyrosine hydroxylase.	0.740
TH	INS	ENSGALP00000051175	ENSGALP00000010567	Tyrosine hydroxylase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.583