STRINGSTRING
PAX1 PAX1 LMO2 LMO2 OVAL OVAL HBBA HBBA GATA2 GATA2 KLF11 KLF11 NR2F2 NR2F2 SOX6 SOX6 LDB1 LDB1 BCL11A BCL11A TFCP2 TFCP2 MYB MYB RUNX1 RUNX1 HBA1 HBA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAX1Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity). (426 aa)
LMO2LIM domain only 2. (216 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
HBBAHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
GATA2GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (466 aa)
KLF11Uncharacterized protein. (530 aa)
NR2F2COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (410 aa)
SOX6HMG box domain-containing protein. (817 aa)
LDB1LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. (416 aa)
BCL11AUncharacterized protein. (796 aa)
TFCP2Transcription factor CP2; Binds the B-response element 5'-CAAGTCCAGGCAAGT-3' of the ENS1/ERNI promoter. May be the major transcription activator thus being essential for its expression; Belongs to the grh/CP2 family. CP2 subfamily. (506 aa)
MYBTranscriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. (785 aa)
RUNX1Runt-related transcription factor. (472 aa)
HBA1Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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