STRINGSTRING
FGF7 FGF7 FGF3 FGF3 FGF11 FGF11 PAX6 PAX6 DLX6 DLX6 DLX5 DLX5 FGF8 FGF8 FGF20 FGF20 FGF14 FGF14 SPRY2 SPRY2 FGF6 FGF6 SIX4 SIX4 GATA2 GATA2 FGF16 FGF16 NEUROD1 NEUROD1 FGF23 FGF23 FGF9 FGF9 SOX9 SOX9 GATA3 GATA3 CASP3 CASP3 FOXI2 FOXI2 SLC26A4 SLC26A4 FGF5 FGF5 FGF10 FGF10 NEUROG1 NEUROG1 AXIN2 AXIN2 FGF18 FGF18 FOXG1 FOXG1 FGF13 FGF13 EYA1 EYA1 FGF12 FGF12 EYA2 EYA2 FGF22 FGF22 FGFR1 FGFR1 SIX1 SIX1 SOX2 SOX2 OTX2 OTX2 PAX2 PAX2 FGFR2 FGFR2 FOXI3 FOXI3 FGF19 FGF19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
PAX6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
DLX6Homeobox domain-containing protein. (283 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
SPRY2Protein sprouty homolog 2; May play an important role in FGF-mediated patterning of the mid/hindbrain region by acting to modulate the signaling effects of FGF8 through participation in a regulatory negative feedback loop. (313 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SIX4SIX homeobox 4. (776 aa)
GATA2GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (466 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
FOXI2Fork-head domain-containing protein. (111 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (816 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
FGF10Uncharacterized protein. (261 aa)
NEUROG1Neurogenin 1. (179 aa)
AXIN2Uncharacterized protein. (837 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
EYA1Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (631 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
FGFR1Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers re [...] (819 aa)
SIX1Sine oculis-related homeobox 1 homolog. (282 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
OTX2Homeodomain transcription factor. (289 aa)
PAX2Paired-box containing protein Pax-2. (394 aa)
FGFR2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (824 aa)
FOXI3Fork-head domain-containing protein. (395 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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