22 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

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gene fusions

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	S100A4	EF-hand domain-containing protein. (101 aa)
	CD34	CD34 molecule. (385 aa)
	NF1	Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. (2865 aa)
	SHH	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
	KITLG	Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa)
	BMP4	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
	DCT	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	FOXE3	Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis. (386 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	S100A4-2	EF-hand domain-containing protein. (100 aa)
	COL17A1	120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. (1510 aa)
	NFIB	Nuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (560 aa)
	SOX2	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
	AXIN2	Uncharacterized protein. (837 aa)
	WNT3A	Protein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250\|UniProtKB:P56704. (376 aa)
	PAX3	Paired-box transcription factor protein PAX3. (484 aa)
	FGF10	Uncharacterized protein. (261 aa)
	MITF	BHLH domain-containing protein. (519 aa)
	NFATC1	Nuclear factor of activated T cells 1. (909 aa)
	MC1R	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (314 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSGALP00000054778	ENSGALP00000020289	Uncharacterized protein.	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	0.706
AXIN2	FGF10	ENSGALP00000054778	ENSGALP00000065453	Uncharacterized protein.	Uncharacterized protein.	0.641
AXIN2	FGF7	ENSGALP00000054778	ENSGALP00000042868	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.602
AXIN2	FGF9	ENSGALP00000054778	ENSGALP00000041598	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.626
AXIN2	SHH	ENSGALP00000054778	ENSGALP00000010292	Uncharacterized protein.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.660
AXIN2	SOX2	ENSGALP00000054778	ENSGALP00000045318	Uncharacterized protein.	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.	0.509
AXIN2	WNT3A	ENSGALP00000054778	ENSGALP00000057582	Uncharacterized protein.	Protein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250\|UniProtKB:P56704.	0.866
BMP4	AXIN2	ENSGALP00000020289	ENSGALP00000054778	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Uncharacterized protein.	0.706
BMP4	CD34	ENSGALP00000020289	ENSGALP00000001784	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	CD34 molecule.	0.620
BMP4	FGF10	ENSGALP00000020289	ENSGALP00000065453	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Uncharacterized protein.	0.921
BMP4	FGF7	ENSGALP00000020289	ENSGALP00000042868	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.854
BMP4	FGF9	ENSGALP00000020289	ENSGALP00000041598	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.865
BMP4	FOXE3	ENSGALP00000020289	ENSGALP00000041809	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis.	0.605
BMP4	KITLG	ENSGALP00000020289	ENSGALP00000018246	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity).	0.520
BMP4	PAX3	ENSGALP00000020289	ENSGALP00000057906	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Paired-box transcription factor protein PAX3.	0.727
BMP4	SHH	ENSGALP00000020289	ENSGALP00000010292	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.964
BMP4	SOX2	ENSGALP00000020289	ENSGALP00000045318	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.	0.801
BMP4	WNT3A	ENSGALP00000020289	ENSGALP00000057582	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	Protein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250\|UniProtKB:P56704.	0.867
CD34	BMP4	ENSGALP00000001784	ENSGALP00000020289	CD34 molecule.	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	0.620
CD34	FGF10	ENSGALP00000001784	ENSGALP00000065453	CD34 molecule.	Uncharacterized protein.	0.550