24 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDC20	WD_REPEATS_REGION domain-containing protein. (507 aa)
	RBX1	RING-type domain-containing protein. (108 aa)
	UBE2B	Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	CACUL1	Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
	FANCE	FA_FANCE domain-containing protein. (244 aa)
	BMI1	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. (326 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	FANCA	Fanconi_A_N domain-containing protein. (1653 aa)
	UBE2Z	Ubiquitin conjugating enzyme E2 Z. (359 aa)
	PTTG2	Uncharacterized protein. (193 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (605 aa)
	RNF4	RING-type domain-containing protein. (194 aa)
	FANCM	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa)
	SHARPIN	SHANK associated RH domain interactor. (481 aa)
	UBA6	Ubiquitin like modifier activating enzyme 6. (1021 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	BRCA1	Uncharacterized protein. (1749 aa)
	BARD1	Uncharacterized protein. (795 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (423 aa)
	FANCD2	Uncharacterized protein. (1510 aa)
	NEDD4	E3 ubiquitin-protein ligase. (932 aa)
	UBE2G2	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
	FANCI	Uncharacterized protein. (1339 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BMI1	ENSGALP00000005502	ENSGALP00000051910	Uncharacterized protein.	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.	0.703
BARD1	BRCA1	ENSGALP00000005502	ENSGALP00000004383	Uncharacterized protein.	Uncharacterized protein.	0.999
BARD1	CDC20	ENSGALP00000005502	ENSGALP00000016189	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.632
BARD1	FANCA	ENSGALP00000005502	ENSGALP00000000704	Uncharacterized protein.	Fanconi_A_N domain-containing protein.	0.607
BARD1	FANCD2	ENSGALP00000005502	ENSGALP00000005896	Uncharacterized protein.	Uncharacterized protein.	0.854
BARD1	FANCE	ENSGALP00000005502	ENSGALP00000004037	Uncharacterized protein.	FA_FANCE domain-containing protein.	0.467
BARD1	FANCI	ENSGALP00000005502	ENSGALP00000010756	Uncharacterized protein.	Uncharacterized protein.	0.669
BARD1	FANCM	ENSGALP00000005502	ENSGALP00000070244	Uncharacterized protein.	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	0.706
BARD1	MDM2	ENSGALP00000005502	ENSGALP00000016144	Uncharacterized protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.511
BARD1	PCNA	ENSGALP00000005502	ENSGALP00000064149	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.539
BARD1	RNF168	ENSGALP00000005502	ENSGALP00000073716	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.893
BMI1	BARD1	ENSGALP00000051910	ENSGALP00000005502	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.	Uncharacterized protein.	0.703
BMI1	BRCA1	ENSGALP00000051910	ENSGALP00000004383	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.	Uncharacterized protein.	0.688
BMI1	CDC20	ENSGALP00000051910	ENSGALP00000016189	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.	WD_REPEATS_REGION domain-containing protein.	0.542
BMI1	MDM2	ENSGALP00000051910	ENSGALP00000016144	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.460
BMI1	PTEN	ENSGALP00000051910	ENSGALP00000005747	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.568
BMI1	RNF168	ENSGALP00000051910	ENSGALP00000073716	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.430
BRCA1	BARD1	ENSGALP00000004383	ENSGALP00000005502	Uncharacterized protein.	Uncharacterized protein.	0.999
BRCA1	BMI1	ENSGALP00000004383	ENSGALP00000051910	Uncharacterized protein.	Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.	0.688
BRCA1	CDC20	ENSGALP00000004383	ENSGALP00000016189	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.691