STRINGSTRING
GAPDH GAPDH DDB2 DDB2 CAND1 CAND1 RBX1 RBX1 CUL4A CUL4A UBL3 UBL3 DCUN1D5 DCUN1D5 CUL5 CUL5 CUL1 CUL1 KLHL3 KLHL3 CUL4B CUL4B DDB1 DDB1 NAE1 NAE1 CUL2 CUL2 UBA3 UBA3 CACUL1 CACUL1 TCEB1 TCEB1 NEDD8 NEDD8 UBE2M UBE2M ACTB ACTB UBE2F UBE2F
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
DDB2DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1- CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1- CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV [...] (507 aa)
CAND1Cullin associated and neddylation dissociated 1. (1230 aa)
RBX1RING-type domain-containing protein. (108 aa)
CUL4ACullin 4A; Belongs to the cullin family. (767 aa)
UBL3Ubiquitin-like protein. (117 aa)
DCUN1D5DCN1-like protein. (236 aa)
CUL5Cullin 5; Belongs to the cullin family. (662 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
KLHL3Kelch like family member 3. (593 aa)
CUL4BCullin 4B; Belongs to the cullin family. (883 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein li [...] (1139 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). (535 aa)
CUL2CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
UBA3Ubiquitin like modifier activating enzyme 3. (442 aa)
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
TCEB1Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
NEDD8NEDD8 ubiquitin like modifier. (85 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
UBE2FNEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. (272 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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