STRINGSTRING
CREBBP CREBBP WNT8A WNT8A PAX3 PAX3 ALDH1A2 ALDH1A2 KDM4B KDM4B FGF10 FGF10 FGF5 FGF5 GATA3 GATA3 PAX6 PAX6 FGF11 FGF11 FGF6 FGF6 SIX4 SIX4 GATA2 GATA2 FGF8 FGF8 WNT6 WNT6 FGF9 FGF9 FOXE3 FOXE3 FGF23 FGF23 FGF3 FGF3 FGF7 FGF7 FGF19 FGF19 EYA4 EYA4 PAX2 PAX2 OTX2 OTX2 SOX2 SOX2 CYP26A1 CYP26A1 SIX1 SIX1 FGFR1 FGFR1 FGF22 FGF22 EYA2 EYA2 FOXA1 FOXA1 FGF12 FGF12 EYA1 EYA1 GBX2 GBX2 FGF13 FGF13 ZIC1 ZIC1 FOXI1 FOXI1 SHH SHH FGF4 FGF4 FGF16 FGF16 DLX5 DLX5 BMP4 BMP4 TFAP2A TFAP2A FGF20 FGF20 MSX1 MSX1 FGF14 FGF14 FGF18 FGF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREBBPCREB binding protein. (2522 aa)
WNT8AProtein Wnt-8c; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Is likely to signal over only few cell diameters. May be involved in the regulation of axis formation and in the rhombomere specification; Belongs to the Wnt family. (357 aa)
PAX3Paired-box transcription factor protein PAX3. (484 aa)
ALDH1A2Retinal dehydrogenase 2; Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral. (499 aa)
KDM4BLysine demethylase 4B. (1168 aa)
FGF10Uncharacterized protein. (261 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
GATA3GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
PAX6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SIX4SIX homeobox 4. (776 aa)
GATA2GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (466 aa)
FGF8Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FOXE3Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis. (386 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
FGF3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
EYA4Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...] (645 aa)
PAX2Paired-box containing protein Pax-2. (394 aa)
OTX2Homeodomain transcription factor. (289 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
CYP26A1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
SIX1Sine oculis-related homeobox 1 homolog. (282 aa)
FGFR1Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers re [...] (819 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (631 aa)
FOXA1Forkhead box A1. (442 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
EYA1Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa)
GBX2Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
ZIC1Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity). (444 aa)
FOXI1Forkhead box I1. (375 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
FGF4Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). (194 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
BMP4Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
TFAP2ATF_AP-2 domain-containing protein. (437 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MSX1Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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