7 items (Gallus gallus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
	DCT	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa)
	SLC45A2	Uncharacterized protein. (543 aa)
	AGRP	Agouti-related protein. (233 aa)
	PMEL	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. (740 aa)
	MC1R	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (314 aa)
	SLC24A5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (423 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	MC1R	ENSGALP00000003505	ENSGALP00000071620	Agouti-related protein.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	0.717
DCT	MC1R	ENSGALP00000035733	ENSGALP00000071620	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	0.768
DCT	PMEL	ENSGALP00000035733	ENSGALP00000051268	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.844
DCT	SLC24A5	ENSGALP00000035733	ENSGALP00000038183	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.653
DCT	SLC45A2	ENSGALP00000035733	ENSGALP00000005236	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	Uncharacterized protein.	0.781
DCT	TYRP1	ENSGALP00000035733	ENSGALP00000037537	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.941
MC1R	AGRP	ENSGALP00000071620	ENSGALP00000003505	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Agouti-related protein.	0.717
MC1R	DCT	ENSGALP00000071620	ENSGALP00000035733	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	0.768
MC1R	PMEL	ENSGALP00000071620	ENSGALP00000051268	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.751
MC1R	SLC24A5	ENSGALP00000071620	ENSGALP00000038183	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.770
MC1R	SLC45A2	ENSGALP00000071620	ENSGALP00000005236	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.861
MC1R	TYRP1	ENSGALP00000071620	ENSGALP00000037537	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.904
PMEL	DCT	ENSGALP00000051268	ENSGALP00000035733	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	0.844
PMEL	MC1R	ENSGALP00000051268	ENSGALP00000071620	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	0.751
PMEL	SLC24A5	ENSGALP00000051268	ENSGALP00000038183	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.788
PMEL	SLC45A2	ENSGALP00000051268	ENSGALP00000005236	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	Uncharacterized protein.	0.865
PMEL	TYRP1	ENSGALP00000051268	ENSGALP00000037537	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.915
SLC24A5	DCT	ENSGALP00000038183	ENSGALP00000035733	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	0.653
SLC24A5	MC1R	ENSGALP00000038183	ENSGALP00000071620	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	0.770
SLC24A5	PMEL	ENSGALP00000038183	ENSGALP00000051268	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.788