node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | INS | ENSGALP00000044604 | ENSGALP00000010567 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.975 |
CACUL1 | NEDD8 | ENSGALP00000055119 | ENSGALP00000055513 | Cullin domain-containing protein; Belongs to the cullin family. | NEDD8 ubiquitin like modifier. | 0.776 |
CACUL1 | RBX1 | ENSGALP00000055119 | ENSGALP00000019539 | Cullin domain-containing protein; Belongs to the cullin family. | RING-type domain-containing protein. | 0.709 |
CACUL1 | SPOPL | ENSGALP00000055119 | ENSGALP00000066899 | Cullin domain-containing protein; Belongs to the cullin family. | Speckle type BTB/POZ protein like. | 0.661 |
CUL3 | GLI2 | ENSGALP00000008177 | ENSGALP00000018975 | Cullin 3; Belongs to the cullin family. | Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). | 0.950 |
CUL3 | GLI3 | ENSGALP00000008177 | ENSGALP00000048561 | Cullin 3; Belongs to the cullin family. | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. | 0.934 |
CUL3 | KLHL3 | ENSGALP00000008177 | ENSGALP00000048576 | Cullin 3; Belongs to the cullin family. | Kelch like family member 3. | 0.869 |
CUL3 | NEDD8 | ENSGALP00000008177 | ENSGALP00000055513 | Cullin 3; Belongs to the cullin family. | NEDD8 ubiquitin like modifier. | 0.985 |
CUL3 | RBX1 | ENSGALP00000008177 | ENSGALP00000019539 | Cullin 3; Belongs to the cullin family. | RING-type domain-containing protein. | 0.999 |
CUL3 | SPOPL | ENSGALP00000008177 | ENSGALP00000066899 | Cullin 3; Belongs to the cullin family. | Speckle type BTB/POZ protein like. | 0.996 |
GLI2 | CUL3 | ENSGALP00000018975 | ENSGALP00000008177 | Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). | Cullin 3; Belongs to the cullin family. | 0.950 |
GLI2 | GLI3 | ENSGALP00000018975 | ENSGALP00000048561 | Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. | 0.913 |
GLI2 | RBX1 | ENSGALP00000018975 | ENSGALP00000019539 | Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). | RING-type domain-containing protein. | 0.499 |
GLI2 | SPOPL | ENSGALP00000018975 | ENSGALP00000066899 | Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). | Speckle type BTB/POZ protein like. | 0.974 |
GLI3 | CUL3 | ENSGALP00000048561 | ENSGALP00000008177 | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. | Cullin 3; Belongs to the cullin family. | 0.934 |
GLI3 | GLI2 | ENSGALP00000048561 | ENSGALP00000018975 | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. | Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Binds to the DNA sequence 5'-GAACCACCCA-3' (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development (By similarity). | 0.913 |
GLI3 | RBX1 | ENSGALP00000048561 | ENSGALP00000019539 | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. | RING-type domain-containing protein. | 0.499 |
GLI3 | SPOPL | ENSGALP00000048561 | ENSGALP00000066899 | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. | Speckle type BTB/POZ protein like. | 0.968 |
INS | ALB | ENSGALP00000010567 | ENSGALP00000044604 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. | 0.975 |
KLHL3 | CUL3 | ENSGALP00000048576 | ENSGALP00000008177 | Kelch like family member 3. | Cullin 3; Belongs to the cullin family. | 0.869 |