39 items (Gallus gallus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MYB	Transcriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. (785 aa)
	AQP3	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
	SOX6	HMG box domain-containing protein. (817 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	FGF4	Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). (194 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	KITLG	Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	CITED2	Cited2/melanocyte specific gene-related gene 1 MRG1. (236 aa)
	ALDH1A1	Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). (509 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	GATA2	GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (466 aa)
	FGF8	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa)
	HBE1	Beta-H globin; Belongs to the globin family. (147 aa)
	HBBA	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	FGF23	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
	FGF3	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa)
	RRAGD	Ras related GTP binding D. (555 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
	LMO2	LIM domain only 2. (216 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
	HBA1	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	LIN28B	Protein lin-28 homolog B; Suppressor of specific microRNA (miRNA) biogenesis. Binds target primary miRNA transcripts and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. The specific interaction with target pri-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Belongs to the lin-28 family. (281 aa)
	LDB1	LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. (416 aa)
	BCL11A	Uncharacterized protein. (796 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF10	Uncharacterized protein. (261 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa)
	RUNX1	Runt-related transcription factor. (472 aa)
	ZFPM1	Zinc finger protein, FOG family member 1. (1079 aa)
	PAX6	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	FGF10	ENSGALP00000044604	ENSGALP00000065453	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Uncharacterized protein.	0.681
ALB	FGF11	ENSGALP00000044604	ENSGALP00000073219	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.628
ALB	FGF12	ENSGALP00000044604	ENSGALP00000051076	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.628
ALB	FGF13	ENSGALP00000044604	ENSGALP00000054094	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.666
ALB	FGF14	ENSGALP00000044604	ENSGALP00000027195	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.665
ALB	FGF16	ENSGALP00000044604	ENSGALP00000012648	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.627
ALB	FGF18	ENSGALP00000044604	ENSGALP00000054695	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.677
ALB	FGF19	ENSGALP00000044604	ENSGALP00000043371	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.678
ALB	FGF20	ENSGALP00000044604	ENSGALP00000022184	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.629
ALB	FGF22	ENSGALP00000044604	ENSGALP00000046847	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.631
ALB	FGF23	ENSGALP00000044604	ENSGALP00000042002	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.705
ALB	FGF3	ENSGALP00000044604	ENSGALP00000042296	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family.	0.633
ALB	FGF4	ENSGALP00000044604	ENSGALP00000012214	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity).	0.708
ALB	FGF5	ENSGALP00000044604	ENSGALP00000065598	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.681
ALB	FGF6	ENSGALP00000044604	ENSGALP00000027889	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.669
ALB	FGF7	ENSGALP00000044604	ENSGALP00000042868	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.677
ALB	FGF8	ENSGALP00000044604	ENSGALP00000032574	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family.	0.693
ALB	FGF9	ENSGALP00000044604	ENSGALP00000041598	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.626
ALB	INS	ENSGALP00000044604	ENSGALP00000010567	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.975
ALB	KITLG	ENSGALP00000044604	ENSGALP00000018246	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Processed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity).	0.476