STRINGSTRING
SST SST CRHR1 CRHR1 AGRP AGRP INS INS LOC417800 LOC417800 NPY NPY PRL PRL MC4R MC4R PNOC PNOC NMU NMU LEPR LEPR GCG GCG NPVF NPVF OPRL1 OPRL1 FOS FOS LOC772096 LOC772096 MC3R MC3R PPY PPY INSR INSR PRLH PRLH QRFPR QRFPR PYY PYY ADCYAP1 ADCYAP1 GCGR GCGR MLN MLN NPS NPS NMS NMS MC1R MC1R NPY2R NPY2R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
CRHR1Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. (420 aa)
AGRPAgouti-related protein. (233 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
LOC417800Uncharacterized protein. (225 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
PRLProlactin. (229 aa)
MC4RG_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
PNOCUncharacterized protein. (194 aa)
NMUNeuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. (181 aa)
LEPRUncharacterized protein. (1148 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
NPVFGonadotropin-inhibitory hormone. (173 aa)
OPRL1Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
LOC772096Glucagon receptor-like protein; Belongs to the G-protein coupled receptor 2 family. (430 aa)
MC3RMelanocortin 3 receptor. (325 aa)
PPYPancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. (80 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
PRLHUncharacterized protein. (87 aa)
QRFPROrexigenic neuropeptide QRFP receptor; Belongs to the G-protein coupled receptor 1 family. (430 aa)
PYYPeptide YY-like; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Belongs to the NPY family. (90 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide 27; Primary role of GRF is to release GH from the pituitary; Belongs to the glucagon family. (172 aa)
GCGRUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (532 aa)
MLNMotilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle; Belongs to the motilin family. (115 aa)
NPSNeuropeptide S. (99 aa)
NMSNeuromedin S long isoform. (150 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (314 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (385 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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