27 items (Gallus gallus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	CCK	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa)
	LOC771308	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (423 aa)
	CRHR1	Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. (420 aa)
	GALR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	OPN1MSW	Green-sensitive opsin; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (355 aa)
	GHRHR	G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
	PROK2	Prokineticin 2. (109 aa)
	CALCR	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (469 aa)
	NPFFR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (422 aa)
	GALR3	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (405 aa)
	SPX	Spexin hormone. (116 aa)
	PNOC	Uncharacterized protein. (194 aa)
	GPR83	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (423 aa)
	PRLHR	G_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
	RHO	Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (351 aa)
	GNRHR	Type 1/III gonadotropin-releasing hormone receptor hexahelical variant. (354 aa)
	CGNRH-R	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	GALR1	Galanin receptor; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	LOC772096	Glucagon receptor-like protein; Belongs to the G-protein coupled receptor 2 family. (430 aa)
	QRFPR	Orexigenic neuropeptide QRFP receptor; Belongs to the G-protein coupled receptor 1 family. (430 aa)
	GPR19	G protein-coupled receptor 19. (426 aa)
	POMC	Uncharacterized protein. (251 aa)
	GCGR	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (532 aa)
	PROK1	Prokineticin 1. (99 aa)
	NPS	Neuropeptide S. (99 aa)
	QRFP	Uncharacterized protein. (122 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALCR	GPR19	ENSGALP00000015462	ENSGALP00000059446	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	G protein-coupled receptor 19.	0.510
CALCR	GPR83	ENSGALP00000015462	ENSGALP00000027767	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.473
CALCR	POMC	ENSGALP00000015462	ENSGALP00000063133	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.403
CALCR	PRLHR	ENSGALP00000015462	ENSGALP00000032414	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.418
CALCR	QRFP	ENSGALP00000015462	ENSGALP00000071229	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.477
CCK	GCG	ENSGALP00000044506	ENSGALP00000032494	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis.	0.923
CCK	NPFFR2	ENSGALP00000044506	ENSGALP00000018955	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.700
CCK	NPS	ENSGALP00000044506	ENSGALP00000070827	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Neuropeptide S.	0.676
CCK	POMC	ENSGALP00000044506	ENSGALP00000063133	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Uncharacterized protein.	0.805
CCK	PRLHR	ENSGALP00000044506	ENSGALP00000032414	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.406
CCK	PROK1	ENSGALP00000044506	ENSGALP00000069911	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Prokineticin 1.	0.529
CCK	PROK2	ENSGALP00000044506	ENSGALP00000012612	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Prokineticin 2.	0.565
CCK	QRFP	ENSGALP00000044506	ENSGALP00000071229	Cholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.	Uncharacterized protein.	0.507
CGNRH-R	GHRHR	ENSGALP00000033143	ENSGALP00000008360	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family.	0.568
CGNRH-R	GNRHR	ENSGALP00000033143	ENSGALP00000032941	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Type 1/III gonadotropin-releasing hormone receptor hexahelical variant.	0.905
CGNRH-R	LOC771308	ENSGALP00000033143	ENSGALP00000000360	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.543
CGNRH-R	NPS	ENSGALP00000033143	ENSGALP00000070827	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Neuropeptide S.	0.447
CGNRH-R	POMC	ENSGALP00000033143	ENSGALP00000063133	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.452
CGNRH-R	PROK1	ENSGALP00000033143	ENSGALP00000069911	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Prokineticin 1.	0.476
CGNRH-R	PROK2	ENSGALP00000033143	ENSGALP00000012612	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Prokineticin 2.	0.713