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XPO1 XPO1 IFNA3 IFNA3 SUMO1 SUMO1 USP8-2 USP8-2 THOC5 THOC5 GAPDH GAPDH ACTB ACTB THOC1 THOC1 THOC2 THOC2 NEDD8 NEDD8 TCEB1 TCEB1 RBX1 RBX1 RAD50 RAD50 USP47 USP47 ALB ALB CUL5 CUL5 STAT1 STAT1 NXF1 NXF1 UBR5 UBR5 STAT2 STAT2 NUDC NUDC USP7 USP7 CACUL1 CACUL1 CAND1 CAND1 SIN3A SIN3A E2F1 E2F1 ALYREF ALYREF ATRX ATRX ANP32A ANP32A SRSF3 SRSF3 USP8 USP8 CEP170 CEP170 HNRNPR HNRNPR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XPO1Importin N-terminal domain-containing protein. (1071 aa)
IFNA3Interferon. (193 aa)
SUMO1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as [...] (135 aa)
USP8-2Rhodanese domain-containing protein. (602 aa)
THOC5THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity); Belongs to t [...] (698 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
THOC1Death domain-containing protein. (671 aa)
THOC2THO complex 2. (1505 aa)
NEDD8NEDD8 ubiquitin like modifier. (85 aa)
TCEB1Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
RBX1RING-type domain-containing protein. (108 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). (1376 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
CUL5Cullin 5; Belongs to the cullin family. (662 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
NXF1Uncharacterized protein. (615 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2756 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
NUDCNuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity). (341 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). (1102 aa)
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
CAND1Cullin associated and neddylation dissociated 1. (1230 aa)
SIN3AHDAC_interact domain-containing protein. (1274 aa)
E2F1Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa)
ALYREFRRM domain-containing protein. (255 aa)
ATRXATRX chromatin remodeler. (2420 aa)
ANP32ALRRcap domain-containing protein. (291 aa)
SRSF3RRM domain-containing protein. (164 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (331 aa)
CEP170Centrosomal protein 170. (1649 aa)
HNRNPRUncharacterized protein. (661 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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