node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | CASP18 | ENSGALP00000060844 | ENSGALP00000065273 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Initiator caspase; Belongs to the peptidase C14A family. | 0.752 |
ACTB | CASP3 | ENSGALP00000060844 | ENSGALP00000068843 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Caspase-3; Belongs to the peptidase C14A family. | 0.995 |
ACTB | CASP8 | ENSGALP00000060844 | ENSGALP00000013591 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.759 |
ACTB | CYP1A1 | ENSGALP00000060844 | ENSGALP00000039219 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.410 |
ACTB | DNTT | ENSGALP00000060844 | ENSGALP00000032645 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. | 0.741 |
ACTB | ESR1 | ENSGALP00000060844 | ENSGALP00000073938 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.798 |
ACTB | SMAD7 | ENSGALP00000060844 | ENSGALP00000054584 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Mothers against decapentaplegic homolog. | 0.480 |
AHR | ARNT | ENSGALP00000047347 | ENSGALP00000071342 | Uncharacterized protein. | Uncharacterized protein. | 0.916 |
AHR | CYP1A1 | ENSGALP00000047347 | ENSGALP00000039219 | Uncharacterized protein. | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.458 |
AHR | CYP1B1 | ENSGALP00000047347 | ENSGALP00000048510 | Uncharacterized protein. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.636 |
AHR | LOC100859347 | ENSGALP00000047347 | ENSGALP00000006877 | Uncharacterized protein. | Uncharacterized protein. | 0.557 |
ARNT | AHR | ENSGALP00000071342 | ENSGALP00000047347 | Uncharacterized protein. | Uncharacterized protein. | 0.916 |
ARNT | CYP1A1 | ENSGALP00000071342 | ENSGALP00000039219 | Uncharacterized protein. | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.746 |
ARNT | CYP1B1 | ENSGALP00000071342 | ENSGALP00000048510 | Uncharacterized protein. | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. | 0.729 |
ARNT | ESR1 | ENSGALP00000071342 | ENSGALP00000073938 | Uncharacterized protein. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.424 |
ARNT | LOC100859347 | ENSGALP00000071342 | ENSGALP00000006877 | Uncharacterized protein. | Uncharacterized protein. | 0.871 |
CASP18 | ACTB | ENSGALP00000065273 | ENSGALP00000060844 | Initiator caspase; Belongs to the peptidase C14A family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.752 |
CASP18 | CASP3 | ENSGALP00000065273 | ENSGALP00000068843 | Initiator caspase; Belongs to the peptidase C14A family. | Caspase-3; Belongs to the peptidase C14A family. | 0.968 |
CASP18 | CASP8 | ENSGALP00000065273 | ENSGALP00000013591 | Initiator caspase; Belongs to the peptidase C14A family. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.915 |
CASP18 | DNTT | ENSGALP00000065273 | ENSGALP00000032645 | Initiator caspase; Belongs to the peptidase C14A family. | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. | 0.556 |