STRINGSTRING
IRF7 IRF7 ITGB2 ITGB2 CASP8 CASP8 IL2 IL2 TLR3 TLR3 MX1 MX1 IL17A IL17A TLR2B TLR2B IFNW1 IFNW1 MYD88 MYD88 STAT1 STAT1 IFIH1 IFIH1 C3 C3 TLR2A TLR2A STAT2 STAT2 CD14 CD14 STAT4 STAT4 IFNAR1 IFNAR1 NOD1 NOD1 CD8A-2 CD8A-2 CASP18 CASP18 CD4 CD4 IL15 IL15 IFNA3 IFNA3 IRF1 IRF1 CD8A-3 CD8A-3 IL10 IL10 STAT5A STAT5A TLR4 TLR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
ITGB2Integrin beta. (773 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
IL2Interleukin; Belongs to the IL-15/IL-21 family. (143 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
MX1Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus. (705 aa)
IL17AUncharacterized protein. (169 aa)
TLR2BToll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
IFNW1Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family. (203 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
IFIH1Uncharacterized protein. (1102 aa)
C3Uncharacterized protein. (1794 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
CD14Uncharacterized protein. (465 aa)
STAT4Signal transducer and activator of transcription. (749 aa)
IFNAR1Uncharacterized protein. (569 aa)
NOD1Uncharacterized protein. (951 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
CD4Uncharacterized protein. (487 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
IFNA3Interferon. (193 aa)
IRF1Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family. (414 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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