node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC42 | COL3A1 | ENSGALP00000065867 | ENSGALP00000051057 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.720 |
CDC42 | RAC1 | ENSGALP00000065867 | ENSGALP00000011538 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] | GTPase cRac1A. | 0.798 |
CDC42 | RHOA | ENSGALP00000065867 | ENSGALP00000033584 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] | GTP-binding protein. | 0.477 |
COL3A1 | CDC42 | ENSGALP00000051057 | ENSGALP00000065867 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] | 0.720 |
COL3A1 | ESR1 | ENSGALP00000051057 | ENSGALP00000073938 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.612 |
COL3A1 | FN1 | ENSGALP00000051057 | ENSGALP00000005653 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). | 0.999 |
COL3A1 | KRT14 | ENSGALP00000051057 | ENSGALP00000058299 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. | 0.532 |
COL3A1 | RHOA | ENSGALP00000051057 | ENSGALP00000033584 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | GTP-binding protein. | 0.780 |
COL3A1 | SOX10 | ENSGALP00000051057 | ENSGALP00000020056 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. | 0.483 |
COL3A1 | TYR | ENSGALP00000051057 | ENSGALP00000027812 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. | 0.400 |
COL3A1 | VTN | ENSGALP00000051057 | ENSGALP00000005668 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | SMB domain-containing protein. | 0.985 |
DCT | EDN3 | ENSGALP00000035733 | ENSGALP00000056488 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Endothelin 3. | 0.701 |
DCT | MITF | ENSGALP00000035733 | ENSGALP00000070157 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | BHLH domain-containing protein. | 0.861 |
DCT | SOX10 | ENSGALP00000035733 | ENSGALP00000020056 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. | 0.831 |
DCT | TYR | ENSGALP00000035733 | ENSGALP00000027812 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. | 0.781 |
DCT | TYRP1 | ENSGALP00000035733 | ENSGALP00000037537 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. | 0.941 |
EDN3 | DCT | ENSGALP00000056488 | ENSGALP00000035733 | Endothelin 3. | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. | 0.701 |
EDN3 | MITF | ENSGALP00000056488 | ENSGALP00000070157 | Endothelin 3. | BHLH domain-containing protein. | 0.675 |
EDN3 | SOX10 | ENSGALP00000056488 | ENSGALP00000020056 | Endothelin 3. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. | 0.845 |
EDN3 | TYR | ENSGALP00000056488 | ENSGALP00000027812 | Endothelin 3. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. | 0.717 |