22 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	FECH	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family. (408 aa)
	NPRL2	Uncharacterized protein. (378 aa)
	NME4	Nucleoside diphosphate kinase. (186 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
	RHBDF1	Rhomboid 5 homolog 1. (902 aa)
	HBZ	Hemoglobin subunit pi; The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P; Belongs to the globin family. (142 aa)
	TFRC	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily. (776 aa)
	CPOX	Uncharacterized protein. (341 aa)
	EBF1	IPT/TIG domain-containing protein. (604 aa)
	GATA2	GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (466 aa)
	HBBA	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
	PGAP6	Transmembrane protein 8A. (761 aa)
	LMO2	LIM domain only 2. (216 aa)
	HBA1	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
	HBAD	Hemoglobin subunit alpha-D; Involved in oxygen transport from the lung to the various peripheral tissues. (141 aa)
	LDB1	LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. (416 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (582 aa)
	CTCF	Transcriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene. (739 aa)
	RBFOX1	RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events. (418 aa)
	BACH2	BTB domain and CNC homolog 2. (850 aa)
	TAL1	T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. (396 aa)
	AXIN1	Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (841 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPOX	FECH	ENSGALP00000024546	ENSGALP00000043525	Uncharacterized protein.	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.	0.969
CPOX	NPRL3	ENSGALP00000024546	ENSGALP00000055100	Uncharacterized protein.	NPR3 like, GATOR1 complex subunit.	0.517
CPOX	PGAP6	ENSGALP00000024546	ENSGALP00000042429	Uncharacterized protein.	Transmembrane protein 8A.	0.584
CTCF	GATA2	ENSGALP00000058125	ENSGALP00000030109	Transcriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene.	GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	0.462
CTCF	LDB1	ENSGALP00000058125	ENSGALP00000053833	Transcriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene.	LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.	0.626
CTCF	TAL1	ENSGALP00000058125	ENSGALP00000073780	Transcriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene.	T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation.	0.521
FECH	CPOX	ENSGALP00000043525	ENSGALP00000024546	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.	Uncharacterized protein.	0.969
FECH	NPRL3	ENSGALP00000043525	ENSGALP00000055100	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.	NPR3 like, GATOR1 complex subunit.	0.422
FECH	PGAP6	ENSGALP00000043525	ENSGALP00000042429	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.	Transmembrane protein 8A.	0.433
FECH	TFRC	ENSGALP00000043525	ENSGALP00000012087	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily.	0.497
GATA2	CTCF	ENSGALP00000030109	ENSGALP00000058125	GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	Transcriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene.	0.462
GATA2	LDB1	ENSGALP00000030109	ENSGALP00000053833	GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.	0.918
GATA2	LMO2	ENSGALP00000030109	ENSGALP00000045476	GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	LIM domain only 2.	0.982
GATA2	TAL1	ENSGALP00000030109	ENSGALP00000073780	GATA-binding factor 2; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation.	0.959
HBA1	HBAD	ENSGALP00000050043	ENSGALP00000053010	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.	Hemoglobin subunit alpha-D; Involved in oxygen transport from the lung to the various peripheral tissues.	0.632
HBA1	HBBA	ENSGALP00000050043	ENSGALP00000035593	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D.	0.995
HBA1	HBZ	ENSGALP00000050043	ENSGALP00000012046	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.	Hemoglobin subunit pi; The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P; Belongs to the globin family.	0.702
HBA1	NPRL3	ENSGALP00000050043	ENSGALP00000055100	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.	NPR3 like, GATOR1 complex subunit.	0.735
HBA1	PGAP6	ENSGALP00000050043	ENSGALP00000042429	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.	Transmembrane protein 8A.	0.719
HBA1	RHBDF1	ENSGALP00000050043	ENSGALP00000012018	Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.	Rhomboid 5 homolog 1.	0.513