(14 nodes) (2017) TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors. network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	PXDNL	Uncharacterized protein. (1406 aa)
	POLE2	DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (555 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	XRCC3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa)
	XRCC6	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (647 aa)
	FANCM	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa)
	BRCA1	Uncharacterized protein. (1749 aa)
	FANCD2	Uncharacterized protein. (1510 aa)
	PXDN	Peroxidasin. (1611 aa)
	BRCA2	Tower domain-containing protein. (3397 aa)
	ATM	Non-specific serine/threonine protein kinase. (3050 aa)
	TOP1	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (747 aa)
	RAD51D	RECA_2 domain-containing protein. (327 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BRCA1	ENSGALP00000027660	ENSGALP00000004383	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.999
ATM	BRCA2	ENSGALP00000027660	ENSGALP00000027524	Non-specific serine/threonine protein kinase.	Tower domain-containing protein.	0.973
ATM	FANCD2	ENSGALP00000027660	ENSGALP00000005896	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.929
ATM	FANCM	ENSGALP00000027660	ENSGALP00000070244	Non-specific serine/threonine protein kinase.	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	0.854
ATM	GAPDH	ENSGALP00000027660	ENSGALP00000063325	Non-specific serine/threonine protein kinase.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.537
ATM	PCNA	ENSGALP00000027660	ENSGALP00000064149	Non-specific serine/threonine protein kinase.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.541
ATM	POLE2	ENSGALP00000027660	ENSGALP00000052295	Non-specific serine/threonine protein kinase.	DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).	0.428
ATM	RAD51D	ENSGALP00000027660	ENSGALP00000049100	Non-specific serine/threonine protein kinase.	RECA_2 domain-containing protein.	0.923
ATM	TOP1	ENSGALP00000027660	ENSGALP00000043331	Non-specific serine/threonine protein kinase.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.732
ATM	XRCC3	ENSGALP00000027660	ENSGALP00000059641	Non-specific serine/threonine protein kinase.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.924
ATM	XRCC6	ENSGALP00000027660	ENSGALP00000053314	Non-specific serine/threonine protein kinase.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...]	0.987
BRCA1	ATM	ENSGALP00000004383	ENSGALP00000027660	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.999
BRCA1	BRCA2	ENSGALP00000004383	ENSGALP00000027524	Uncharacterized protein.	Tower domain-containing protein.	0.999
BRCA1	FANCD2	ENSGALP00000004383	ENSGALP00000005896	Uncharacterized protein.	Uncharacterized protein.	0.993
BRCA1	FANCM	ENSGALP00000004383	ENSGALP00000070244	Uncharacterized protein.	Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...]	0.852
BRCA1	GAPDH	ENSGALP00000004383	ENSGALP00000063325	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.499
BRCA1	PCNA	ENSGALP00000004383	ENSGALP00000064149	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.512
BRCA1	POLE2	ENSGALP00000004383	ENSGALP00000052295	Uncharacterized protein.	DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).	0.606
BRCA1	RAD51D	ENSGALP00000004383	ENSGALP00000049100	Uncharacterized protein.	RECA_2 domain-containing protein.	0.951
BRCA1	TOP1	ENSGALP00000004383	ENSGALP00000043331	Uncharacterized protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.744