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| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (651 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa) |
| | CYP1A2 | Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (418 aa) |
| | SIRT1 | Deacetylase sirtuin-type domain-containing protein. (881 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (423 aa) |
| | UGT1A1 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa) |
| | HNF4A | Uncharacterized protein. (466 aa) |
| | LOC100859347 | Uncharacterized protein. (964 aa) |
| | CYP3A4 | Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa) |
| | IRS1 | Insulin receptor substrate 1. (1178 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa) |
| | CPT1A | Carnitine palmitoyltransferase I; Belongs to the carnitine/choline acetyltransferase family. (770 aa) |
| | ABCC2 | Uncharacterized protein. (1538 aa) |
| | ABCC3 | Uncharacterized protein. (1529 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa) |
| | CALML4 | Uncharacterized protein. (153 aa) |
| | XDH | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. (1358 aa) |
| | EPHX1 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (464 aa) |
| | SLC2A2 | Solute carrier family 2, facilitated glucose transporter member 2; Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. Also able to mediate the transport of dehydroascorbate. (533 aa) |
| | PDK4 | Protein-serine/threonine kinase. (414 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa) |
| | ABCG5 | ATP binding cassette subfamily G member 5. (630 aa) |
| | GPX7 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa) |
| | G6PC2 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa) |
| | ESR2 | Estrogen receptor beta; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Belongs to the nuclear hormone receptor family. NR3 subfamily. (472 aa) |
| | UGT2A1 | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa) |
| | LCT | Uncharacterized protein. (1935 aa) |
| | BCL2 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa) |
| | HMGCR | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (930 aa) |
| | SLC2A14 | Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (496 aa) |
| | HMOX1 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. (317 aa) |
| | ABCB1-2 | Multidrug resistance protein 1. (1288 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...] (1011 aa) |
| | BIRC5 | Uncharacterized protein. (142 aa) |
| | LDHA | L-lactate dehydrogenase A chain; Belongs to the LDH/MDH superfamily. LDH family. (332 aa) |
| | CYP1A1 | Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa) |
| | CALML3 | Calmodulin, striated muscle; Belongs to the calmodulin family. (149 aa) |
| | TIMP3 | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli; Belongs to the protease inhibitor I35 (TIMP) family. (212 aa) |
| | GPX8 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa) |
| | GPX1 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (182 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa) |
| | EGF | Uncharacterized protein. (1283 aa) |
| | CALM2 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (151 aa) |
| | UGP2 | UTP--glucose-1-phosphate uridylyltransferase. (508 aa) |
| | AHR | Uncharacterized protein. (877 aa) |
| | FASN | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2512 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1324 aa) |
| | TJP2 | Uncharacterized protein; Belongs to the MAGUK family. (1373 aa) |
| | HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa) |
| | IL1B | Interleukin-1; Belongs to the IL-1 family. (267 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase 2 alpha; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription. (760 aa) |
| | ABCB1 | ATP binding cassette subfamily B member 1. (1293 aa) |
| | ERBB3 | Protein kinase domain-containing protein. (1319 aa) |
| | EGFR | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa) |
| | ABCG2 | ATP-binding cassette sub-family G member 2. (701 aa) |
| | RPSAP58 | 40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. (296 aa) |
| | G6PC | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa) |
| | NOS1 | Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa) |
| | MUTYH | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (511 aa) |
| | ENO1 | Alpha-enolase. (447 aa) |
| | CD38 | Uncharacterized protein. (308 aa) |
| | CTSG | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa) |
| | G6PC3 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (342 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa) |
| | MMP9 | Uncharacterized protein. (713 aa) |
| | UGT8 | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. (537 aa) |
| | CASP3 | Caspase-3; Belongs to the peptidase C14A family. (283 aa) |
| | GPX4 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa) |
| | COMT | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (262 aa) |
| | NRF1 | Uncharacterized protein. (579 aa) |
| | ME1 | Malic enzyme. (655 aa) |
| | NOX1 | FAD-binding FR-type domain-containing protein. (564 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa) |
