node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ASCL1 | ENSGALP00000060844 | ENSGALP00000047577 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | BHLH domain-containing protein. | 0.440 |
ACTB | GAD1 | ENSGALP00000060844 | ENSGALP00000053512 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Glutamate decarboxylase 67. | 0.567 |
ACTB | ISL1 | ENSGALP00000060844 | ENSGALP00000043151 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] | 0.711 |
ACTB | MYC | ENSGALP00000060844 | ENSGALP00000072090 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. | 0.856 |
ACTB | OLIG2 | ENSGALP00000060844 | ENSGALP00000047462 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. | 0.666 |
ACTB | POU4F1 | ENSGALP00000060844 | ENSGALP00000046501 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] | 0.429 |
ACTB | SLC17A6 | ENSGALP00000060844 | ENSGALP00000055805 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | MFS domain-containing protein. | 0.431 |
ASCL1 | ACTB | ENSGALP00000047577 | ENSGALP00000060844 | BHLH domain-containing protein. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.440 |
ASCL1 | BHLHE22 | ENSGALP00000047577 | ENSGALP00000052487 | BHLH domain-containing protein. | Class E basic helix-loop-helix protein 22; May act as a transcriptional repressor. | 0.583 |
ASCL1 | GAD1 | ENSGALP00000047577 | ENSGALP00000053512 | BHLH domain-containing protein. | Glutamate decarboxylase 67. | 0.705 |
ASCL1 | ISL1 | ENSGALP00000047577 | ENSGALP00000043151 | BHLH domain-containing protein. | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] | 0.782 |
ASCL1 | LHX1 | ENSGALP00000047577 | ENSGALP00000008672 | BHLH domain-containing protein. | LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. | 0.619 |
ASCL1 | LHX5 | ENSGALP00000047577 | ENSGALP00000013502 | BHLH domain-containing protein. | LIM homeobox protein 5. | 0.479 |
ASCL1 | LMX1B | ENSGALP00000047577 | ENSGALP00000054070 | BHLH domain-containing protein. | LIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development. | 0.653 |
ASCL1 | MYC | ENSGALP00000047577 | ENSGALP00000072090 | BHLH domain-containing protein. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. | 0.453 |
ASCL1 | NEUROG1 | ENSGALP00000047577 | ENSGALP00000057908 | BHLH domain-containing protein. | Neurogenin 1. | 0.872 |
ASCL1 | NKX2-2 | ENSGALP00000047577 | ENSGALP00000054805 | BHLH domain-containing protein. | Homeobox domain-containing protein. | 0.830 |
ASCL1 | OLIG2 | ENSGALP00000047577 | ENSGALP00000047462 | BHLH domain-containing protein. | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. | 0.857 |
ASCL1 | PAX2 | ENSGALP00000047577 | ENSGALP00000045193 | BHLH domain-containing protein. | Paired-box containing protein Pax-2. | 0.553 |
ASCL1 | PHOX2B | ENSGALP00000047577 | ENSGALP00000036658 | BHLH domain-containing protein. | Paired like homeobox 2B. | 0.845 |