STRINGSTRING
LHX5 LHX5 TLX1 TLX1 LHX1 LHX1 MFNG MFNG HOOK3 HOOK3 PHOX2B PHOX2B PTF1A PTF1A OTP OTP ISL1 ISL1 CCBE1 CCBE1 PAX2 PAX2 POU4F1 POU4F1 OLIG2 OLIG2 ASCL1 ASCL1 PRDM8 PRDM8 BHLHE22 BHLHE22 PRDM13 PRDM13 GAD1 GAD1 LMX1B LMX1B NKX2-2 NKX2-2 SLC17A6 SLC17A6 NEUROG1 NEUROG1 ACTB ACTB RBPJ RBPJ MYC MYC PRDM12 PRDM12 TLX3 TLX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LHX5LIM homeobox protein 5. (402 aa)
TLX1T-cell leukemia homeobox protein 1; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (297 aa)
LHX1LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (352 aa)
HOOK3Hook microtubule tethering protein 3. (713 aa)
PHOX2BPaired like homeobox 2B. (292 aa)
PTF1APancreas associated transcription factor 1a. (275 aa)
OTPOrthopedia homeobox. (325 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
CCBE1Collagen and calcium binding EGF domains 1. (329 aa)
PAX2Paired-box containing protein Pax-2. (394 aa)
POU4F1POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
OLIG2Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
ASCL1BHLH domain-containing protein. (219 aa)
PRDM8PR/SET domain 8. (336 aa)
BHLHE22Class E basic helix-loop-helix protein 22; May act as a transcriptional repressor. (309 aa)
PRDM13PR/SET domain 13. (582 aa)
GAD1Glutamate decarboxylase 67. (590 aa)
LMX1BLIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development. (400 aa)
NKX2-2Homeobox domain-containing protein. (272 aa)
SLC17A6MFS domain-containing protein. (585 aa)
NEUROG1Neurogenin 1. (179 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (484 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
PRDM12PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (351 aa)
TLX3T-cell leukemia homeobox protein 3; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (296 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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