STRINGSTRING
MLKL MLKL CD34 CD34 CD8A-2 CD8A-2 CD4 CD4 CASP3 CASP3 RIPK3 RIPK3 CD8A-3 CD8A-3 ACTB ACTB CASP18 CASP18 PRKDC PRKDC IFNAR1 IFNAR1 IL1B IL1B ALB ALB OVAL OVAL CYLD CYLD CASP8 CASP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLKLMixed lineage kinase domain like pseudokinase. (486 aa)
CD34CD34 molecule. (385 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
CD4Uncharacterized protein. (487 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
RIPK3Uncharacterized protein. (424 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...] (4132 aa)
IFNAR1Uncharacterized protein. (569 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (941 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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