8 items (Gallus gallus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	CISH	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...] (258 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	RBX1	RING-type domain-containing protein. (108 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (662 aa)
	CUL2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
	CACUL1	Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
	TPH1	Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (475 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACUL1	CUL5	ENSGALP00000055119	ENSGALP00000045443	Cullin domain-containing protein; Belongs to the cullin family.	Cullin 5; Belongs to the cullin family.	0.402
CACUL1	RBX1	ENSGALP00000055119	ENSGALP00000019539	Cullin domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.709
CISH	CUL2	ENSGALP00000003536	ENSGALP00000050746	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.845
CISH	CUL5	ENSGALP00000003536	ENSGALP00000045443	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	Cullin 5; Belongs to the cullin family.	0.984
CISH	INS	ENSGALP00000003536	ENSGALP00000010567	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.412
CISH	RBX1	ENSGALP00000003536	ENSGALP00000019539	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	RING-type domain-containing protein.	0.647
CUL2	CISH	ENSGALP00000050746	ENSGALP00000003536	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	0.845
CUL2	CUL5	ENSGALP00000050746	ENSGALP00000045443	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Cullin 5; Belongs to the cullin family.	0.851
CUL2	RBX1	ENSGALP00000050746	ENSGALP00000019539	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.999
CUL5	CACUL1	ENSGALP00000045443	ENSGALP00000055119	Cullin 5; Belongs to the cullin family.	Cullin domain-containing protein; Belongs to the cullin family.	0.402
CUL5	CISH	ENSGALP00000045443	ENSGALP00000003536	Cullin 5; Belongs to the cullin family.	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	0.984
CUL5	CUL2	ENSGALP00000045443	ENSGALP00000050746	Cullin 5; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.851
CUL5	RBX1	ENSGALP00000045443	ENSGALP00000019539	Cullin 5; Belongs to the cullin family.	RING-type domain-containing protein.	0.999
INS	CISH	ENSGALP00000010567	ENSGALP00000003536	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	0.412
RBX1	CACUL1	ENSGALP00000019539	ENSGALP00000055119	RING-type domain-containing protein.	Cullin domain-containing protein; Belongs to the cullin family.	0.709
RBX1	CISH	ENSGALP00000019539	ENSGALP00000003536	RING-type domain-containing protein.	Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...]	0.647
RBX1	CUL2	ENSGALP00000019539	ENSGALP00000050746	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.999
RBX1	CUL5	ENSGALP00000019539	ENSGALP00000045443	RING-type domain-containing protein.	Cullin 5; Belongs to the cullin family.	0.999