STRINGSTRING
PIK3R5 PIK3R5 GNRH1 GNRH1 GRIK3 GRIK3 AGRP AGRP MTOR MTOR NPPC-2 NPPC-2 ABCA4 ABCA4 CHRNA4 CHRNA4 SHH SHH INS INS IL13 IL13 CPT1A CPT1A SOCS1 SOCS1 SST SST BMP7 BMP7 NAMPTP1 NAMPTP1 GHRL GHRL TRH TRH PTGFR PTGFR IL22 IL22 TSHR TSHR LRP2 LRP2 NPY NPY NPFFR2 NPFFR2 IL8L1 IL8L1 MC4R MC4R VIP VIP NMBR NMBR AVP AVP NPBWR1 NPBWR1 NFKBIZ NFKBIZ GRM5 GRM5 NPVF NPVF TNFSF15 TNFSF15 NFKBIA NFKBIA IL34 IL34 SOCS3 SOCS3 GAL GAL MC3R MC3R RAX RAX CCK CCK PTH PTH TRHR TRHR INSR INSR IL1B IL1B GLP1R GLP1R GAD1 GAD1 GAD2 GAD2 CCL4 CCL4 CD44 CD44 IGF1R IGF1R ANXA6 ANXA6 PYY PYY ACTB ACTB ACSL1 ACSL1 POMC POMC GAPDH GAPDH ENSGALP00000063679 ENSGALP00000063679 CD83 CD83 LITAF LITAF CNR1 CNR1 CCL4-2 CCL4-2 ABAT ABAT IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. (805 aa)
GNRH1GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; Belongs to the GnRH family. (92 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (919 aa)
AGRPAgouti-related protein. (233 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
NPPC-2C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (130 aa)
ABCA4ATP binding cassette subfamily A member 4. (2272 aa)
CHRNA4Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub- subfamily. (622 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
IL13Interleukin-13. (138 aa)
CPT1ACarnitine palmitoyltransferase I; Belongs to the carnitine/choline acetyltransferase family. (770 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
BMP7Bone morphogenetic protein 7. (465 aa)
NAMPTP1Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (493 aa)
GHRLPreproghrelin. (116 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
PTGFRG_PROTEIN_RECEP_F1_2 domain-containing protein. (354 aa)
IL22Uncharacterized protein. (197 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
LRP2LDL receptor related protein 2. (3187 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
NPFFR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (422 aa)
IL8L1Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
MC4RG_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
VIPIntestinal peptide PHI-27-like; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (200 aa)
NMBRNeuromedin-B receptor; Belongs to the G-protein coupled receptor 1 family. (388 aa)
AVPVasotocin-neurophysin VT; Vasotocin is an antidiuretic hormone. (161 aa)
NPBWR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (331 aa)
NFKBIZANK_REP_REGION domain-containing protein. (618 aa)
GRM5G_PROTEIN_RECEP_F3_4 domain-containing protein. (1242 aa)
NPVFGonadotropin-inhibitory hormone. (173 aa)
TNFSF15TL1A. (239 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
IL34Interleukin 34. (178 aa)
SOCS3Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...] (209 aa)
GALGalanin variant 1. (141 aa)
MC3RMelanocortin 3 receptor. (325 aa)
RAXRetinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (317 aa)
CCKCholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
TRHRThyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (395 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (459 aa)
GAD1Glutamate decarboxylase 67. (590 aa)
GAD2Glutamate decarboxylase 2. (807 aa)
CCL4C-C motif chemokine 4 homolog. (89 aa)
CD44Link domain-containing protein. (696 aa)
IGF1RTyrosine-protein kinase receptor. (1363 aa)
ANXA6Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores (By similarity). (782 aa)
PYYPeptide YY-like; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Belongs to the NPY family. (90 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ACSL1AMP-binding domain-containing protein. (699 aa)
POMCUncharacterized protein. (251 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
ENSGALP00000063679G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (388 aa)
CD83CD83 molecule. (215 aa)
LITAFLipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines. (148 aa)
CNR1Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (495 aa)
CCL4-2C-C motif chemokine 4 homolog; Monokine with inflammatory and chemokinetic properties. (96 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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