STRINGSTRING
ETS1 ETS1 ATF3 ATF3 TSPAN14 TSPAN14 ICOS ICOS IRAK2 IRAK2 CD8A-3 CD8A-3 TLR7 TLR7 TRAF6 TRAF6 SYTL1 SYTL1 MEIS1 MEIS1 IL6 IL6 S1PR1 S1PR1 CD4 CD4 CD8A-2 CD8A-2 NPM1 NPM1 XPO5 XPO5 MAFB MAFB NEDD8 NEDD8 DGCR8 DGCR8 STAT4 STAT4 FLT3 FLT3 IL1B IL1B IRF5 IRF5 CD1C CD1C CXCL12 CXCL12 STAT1 STAT1 FOXP1 FOXP1 MYD88 MYD88 DROSHA DROSHA NFKBIA NFKBIA TNFSF11 TNFSF11 IL4 IL4 PELI3 PELI3 IRF7 IRF7 DICER1 DICER1 IL17A IL17A SYK SYK JARID2 JARID2 CXCR4 CXCR4 TIFA TIFA HOXA9 HOXA9 PRKCE PRKCE FADD FADD SOCS1 SOCS1 TLR4 TLR4 CD40LG CD40LG STAT5A STAT5A STAT3 STAT3 CD34 CD34 IL10 IL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ETS1Transforming protein p68/c-ets-1; Probable transcription factor. (497 aa)
ATF3Activating transcription factor 3. (181 aa)
TSPAN14Tetraspanin. (270 aa)
ICOSIGv domain-containing protein. (232 aa)
IRAK2Protein kinase domain-containing protein. (725 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
SYTL1Uncharacterized protein. (806 aa)
MEIS1Homeobox domain-containing protein. (465 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
CD4Uncharacterized protein. (487 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
NPM1Nucleophosmin; Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single- stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity). Belongs to the nucleoplasmin family. (404 aa)
XPO5Importin N-terminal domain-containing protein. (1220 aa)
MAFBTranscription factor MafB; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha-A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE). (311 aa)
NEDD8NEDD8 ubiquitin like modifier. (85 aa)
DGCR8DGCR8 microprocessor complex subunit. (775 aa)
STAT4Signal transducer and activator of transcription. (749 aa)
FLT3Fms related tyrosine kinase 3. (877 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
IRF5IRF tryptophan pentad repeat domain-containing protein. (472 aa)
CD1CIg-like domain-containing protein. (374 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (167 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
FOXP1Forkhead box protein P1; Transcriptional repressor. (686 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
DROSHAUncharacterized protein. (1336 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
TNFSF11TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (400 aa)
IL4Interleukin 4. (136 aa)
PELI3Uncharacterized protein. (418 aa)
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
DICER1Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1921 aa)
IL17AUncharacterized protein. (169 aa)
SYKTyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] (636 aa)
JARID2Protein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone [...] (1235 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
TIFATRAF interacting protein with forkhead associated domain. (254 aa)
HOXA9Homeobox protein Hox-A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (260 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
FADDFas associated via death domain. (195 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
CD34CD34 molecule. (385 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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