33 items (Gallus gallus) - STRING interaction network

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second shell of interactors

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Your Input:
	PAX2	Paired-box containing protein Pax-2. (394 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
	ISL1	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
	SATB2	DNA-binding protein SATB. (731 aa)
	TUBB2A	Tubulin beta-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (445 aa)
	PTF1A	Pancreas associated transcription factor 1a. (275 aa)
	SMAD5	Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). (465 aa)
	PXDN	Peroxidasin. (1611 aa)
	TUBB2B	Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (445 aa)
	BRE	BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] (383 aa)
	NEUROD1	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
	TUBB4B	Tubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a role in dorsal root ganglion axon projection towards the spinal cord. (445 aa)
	PGK2	Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa)
	BMP7	Bone morphogenetic protein 7. (465 aa)
	LHX1	LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
	TLX3	T-cell leukemia homeobox protein 3; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (296 aa)
	LHX2	LIM homeodomain. (400 aa)
	TUBB1	Tubulin beta-6 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (446 aa)
	HUC	RRM domain-containing protein. (124 aa)
	PAX6	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
	GATA3	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
	NEUROG1	Neurogenin 1. (179 aa)
	TUBB6	Tubulin beta-5 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	EN1	Homeobox protein engrailed-1. (334 aa)
	ID2	Transcriptional regulator Id2. (134 aa)
	PXDNL	Uncharacterized protein. (1406 aa)
	NEUROD2	Neurogenic differentiation factor. (356 aa)
	TBR1	T-box brain transcription factor 1. (677 aa)
	VSX2	Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family. (377 aa)
	ASCL1	BHLH domain-containing protein. (219 aa)
	EVX1	Even-skipped homeobox 1. (402 aa)
	TUBB	Tubulin beta-7 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
	SOX2	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	HUC	ENSGALP00000044604	ENSGALP00000072894	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	RRM domain-containing protein.	0.479
ALB	ISL1	ENSGALP00000044604	ENSGALP00000043151	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	0.465
ALB	PAX6	ENSGALP00000044604	ENSGALP00000070449	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.588
ALB	PGK2	ENSGALP00000044604	ENSGALP00000012878	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.	0.600
ALB	PXDN	ENSGALP00000044604	ENSGALP00000026363	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Peroxidasin.	0.982
ALB	PXDNL	ENSGALP00000044604	ENSGALP00000049777	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Uncharacterized protein.	0.982
ALB	SOX2	ENSGALP00000044604	ENSGALP00000045318	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.	0.626
ASCL1	EN1	ENSGALP00000047577	ENSGALP00000052689	BHLH domain-containing protein.	Homeobox protein engrailed-1.	0.586
ASCL1	GATA3	ENSGALP00000047577	ENSGALP00000068882	BHLH domain-containing protein.	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.	0.626
ASCL1	HUC	ENSGALP00000047577	ENSGALP00000072894	BHLH domain-containing protein.	RRM domain-containing protein.	0.609
ASCL1	ID2	ENSGALP00000047577	ENSGALP00000051620	BHLH domain-containing protein.	Transcriptional regulator Id2.	0.423
ASCL1	ISL1	ENSGALP00000047577	ENSGALP00000043151	BHLH domain-containing protein.	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	0.782
ASCL1	LHX1	ENSGALP00000047577	ENSGALP00000008672	BHLH domain-containing protein.	LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2.	0.619
ASCL1	LHX2	ENSGALP00000047577	ENSGALP00000001691	BHLH domain-containing protein.	LIM homeodomain.	0.693
ASCL1	NEUROD1	ENSGALP00000047577	ENSGALP00000014468	BHLH domain-containing protein.	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	0.484
ASCL1	NEUROD2	ENSGALP00000047577	ENSGALP00000049753	BHLH domain-containing protein.	Neurogenic differentiation factor.	0.761
ASCL1	NEUROG1	ENSGALP00000047577	ENSGALP00000057908	BHLH domain-containing protein.	Neurogenin 1.	0.872
ASCL1	PAX2	ENSGALP00000047577	ENSGALP00000045193	BHLH domain-containing protein.	Paired-box containing protein Pax-2.	0.553
ASCL1	PAX6	ENSGALP00000047577	ENSGALP00000070449	BHLH domain-containing protein.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.854
ASCL1	SOX2	ENSGALP00000047577	ENSGALP00000045318	BHLH domain-containing protein.	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.	0.718