(17 nodes) (2018) TLR Stimulation during T-cell Activation Lowers PD-1 Expression on CD8(+) T Cells. network (Gallus gallus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	TLR1A	TIR domain-containing protein; Belongs to the Toll-like receptor family. (818 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
	CD4	Uncharacterized protein. (487 aa)
	CD244	Ig-like domain-containing protein. (383 aa)
	LAG3	Lymphocyte activating 3. (504 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	TLR2A	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
	EOMES	T-box_assoc domain-containing protein. (661 aa)
	TLR2B	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
	OVAL	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
	CD86	Uncharacterized protein. (319 aa)
	CD80	Uncharacterized protein. (316 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	CTLA4	Cytotoxic T-lymphocyte-associated protein 4. (205 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD244	CD4	ENSGALP00000063344	ENSGALP00000065611	Ig-like domain-containing protein.	Uncharacterized protein.	0.512
CD244	CD8A-2	ENSGALP00000063344	ENSGALP00000059832	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.624
CD244	CD8A-3	ENSGALP00000063344	ENSGALP00000071819	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.624
CD244	CTLA4	ENSGALP00000063344	ENSGALP00000014096	Ig-like domain-containing protein.	Cytotoxic T-lymphocyte-associated protein 4.	0.508
CD244	LAG3	ENSGALP00000063344	ENSGALP00000061028	Ig-like domain-containing protein.	Lymphocyte activating 3.	0.613
CD4	CD244	ENSGALP00000065611	ENSGALP00000063344	Uncharacterized protein.	Ig-like domain-containing protein.	0.512
CD4	CD80	ENSGALP00000065611	ENSGALP00000024911	Uncharacterized protein.	Uncharacterized protein.	0.983
CD4	CD86	ENSGALP00000065611	ENSGALP00000036384	Uncharacterized protein.	Uncharacterized protein.	0.983
CD4	CD8A-2	ENSGALP00000065611	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.984
CD4	CD8A-3	ENSGALP00000065611	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.982
CD4	CTLA4	ENSGALP00000065611	ENSGALP00000014096	Uncharacterized protein.	Cytotoxic T-lymphocyte-associated protein 4.	0.966
CD4	EOMES	ENSGALP00000065611	ENSGALP00000041400	Uncharacterized protein.	T-box_assoc domain-containing protein.	0.736
CD4	IL10	ENSGALP00000065611	ENSGALP00000001310	Uncharacterized protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.982
CD4	LAG3	ENSGALP00000065611	ENSGALP00000061028	Uncharacterized protein.	Lymphocyte activating 3.	0.452
CD4	OVAL	ENSGALP00000065611	ENSGALP00000036403	Uncharacterized protein.	Ovalbumin; Non-inhibitory serpin. Storage protein of egg white.	0.979
CD4	TLR1A	ENSGALP00000065611	ENSGALP00000028126	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.639
CD4	TLR2A	ENSGALP00000065611	ENSGALP00000050968	Uncharacterized protein.	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.856
CD4	TLR2B	ENSGALP00000065611	ENSGALP00000038134	Uncharacterized protein.	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.850
CD4	TLR3	ENSGALP00000065611	ENSGALP00000021914	Uncharacterized protein.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.869
CD4	TLR4	ENSGALP00000065611	ENSGALP00000011319	Uncharacterized protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.888