9 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPR143	Uncharacterized protein. (391 aa)
	SLC45A2	Uncharacterized protein. (543 aa)
	GPNMB	Glycoprotein nmb. (559 aa)
	SOX10	Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa)
	OCA2	OCA2 melanosomal transmembrane protein. (726 aa)
	TYR	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
	KRT75	IF rod domain-containing protein; Belongs to the intermediate filament family. (536 aa)
	PMEL	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. (740 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GPNMB	GPR143	ENSGALP00000017800	ENSGALP00000026765	Glycoprotein nmb.	Uncharacterized protein.	0.570
GPNMB	SLC45A2	ENSGALP00000017800	ENSGALP00000005236	Glycoprotein nmb.	Uncharacterized protein.	0.456
GPNMB	TYR	ENSGALP00000017800	ENSGALP00000027812	Glycoprotein nmb.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.	0.475
GPNMB	TYRP1	ENSGALP00000017800	ENSGALP00000037537	Glycoprotein nmb.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.599
GPR143	GPNMB	ENSGALP00000026765	ENSGALP00000017800	Uncharacterized protein.	Glycoprotein nmb.	0.570
GPR143	KRT75	ENSGALP00000026765	ENSGALP00000044470	Uncharacterized protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.404
GPR143	OCA2	ENSGALP00000026765	ENSGALP00000026970	Uncharacterized protein.	OCA2 melanosomal transmembrane protein.	0.639
GPR143	PMEL	ENSGALP00000026765	ENSGALP00000051268	Uncharacterized protein.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.578
GPR143	SLC45A2	ENSGALP00000026765	ENSGALP00000005236	Uncharacterized protein.	Uncharacterized protein.	0.695
GPR143	TYR	ENSGALP00000026765	ENSGALP00000027812	Uncharacterized protein.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.	0.777
GPR143	TYRP1	ENSGALP00000026765	ENSGALP00000037537	Uncharacterized protein.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.774
KRT75	GPR143	ENSGALP00000044470	ENSGALP00000026765	IF rod domain-containing protein; Belongs to the intermediate filament family.	Uncharacterized protein.	0.404
KRT75	PMEL	ENSGALP00000044470	ENSGALP00000051268	IF rod domain-containing protein; Belongs to the intermediate filament family.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.408
OCA2	GPR143	ENSGALP00000026970	ENSGALP00000026765	OCA2 melanosomal transmembrane protein.	Uncharacterized protein.	0.639
OCA2	PMEL	ENSGALP00000026970	ENSGALP00000051268	OCA2 melanosomal transmembrane protein.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.525
OCA2	SLC45A2	ENSGALP00000026970	ENSGALP00000005236	OCA2 melanosomal transmembrane protein.	Uncharacterized protein.	0.894
OCA2	TYR	ENSGALP00000026970	ENSGALP00000027812	OCA2 melanosomal transmembrane protein.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.	0.926
OCA2	TYRP1	ENSGALP00000026970	ENSGALP00000037537	OCA2 melanosomal transmembrane protein.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.903
PMEL	GPR143	ENSGALP00000051268	ENSGALP00000026765	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	Uncharacterized protein.	0.578
PMEL	KRT75	ENSGALP00000051268	ENSGALP00000044470	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.408