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| | HELLS | Helicase, lymphoid specific. (822 aa) |
| | RGN | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). (299 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa) |
| | KLF12 | Kruppel like factor 12. (396 aa) |
| | LOXL1 | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin; Belongs to the lysyl oxidase family. (511 aa) |
| | LDLR | Uncharacterized protein. (302 aa) |
| | NDRG1 | N-myc downstream regulated 1. (402 aa) |
| | TFPI2 | Tissue factor pathway inhibitor. (239 aa) |
| | SLC27A1 | AMP-binding domain-containing protein. (719 aa) |
| | SLC6A6 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (708 aa) |
| | LPIN1 | Lipin 1. (1003 aa) |
| | PLIN2 | Perilipin; Belongs to the perilipin family. (446 aa) |
| | FABP7 | Fatty acid-binding protein, brain; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa) |
| | DUT | dUTPase domain-containing protein. (187 aa) |
| | TNFSF10 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa) |
| | FNTB | Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (412 aa) |
| | ACSL1 | AMP-binding domain-containing protein. (699 aa) |
| | RPL14 | Ribosomal protein L14. (122 aa) |
| | NFYC | Nuclear transcription factor Y subunit gamma. (447 aa) |
| | KRT8 | IF rod domain-containing protein; Belongs to the intermediate filament family. (541 aa) |
| | COL1A1 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa) |
| | SREBF2 | Sterol regulatory element binding transcription factor 2. (1112 aa) |
| | SOX7 | Uncharacterized protein. (377 aa) |
| | LPIN2 | LNS2 domain-containing protein. (918 aa) |
| | FOXO1 | Fork-head domain-containing protein. (727 aa) |
| | LRP1 | Low-density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor. Belongs to the LDLR family. (4583 aa) |
| | TNFRSF1B | Uncharacterized protein. (462 aa) |
| | IGFBP1 | Uncharacterized protein. (269 aa) |
| | GGA1 | Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (665 aa) |
| | THRSP | Thyroid hormone responsive spot 14 alpha 2. (129 aa) |
| | KLF10 | Kruppel like factor 10. (436 aa) |
| | ENPP2 | Uncharacterized protein. (859 aa) |
| | FABP5 | FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (291 aa) |
| | PPARGC1A | RRM domain-containing protein. (795 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa) |
| | HSD17B12 | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (401 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (808 aa) |
| | VNN1-2 | CN hydrolase domain-containing protein. (187 aa) |
| | SIK1 | Serine/threonine-protein kinase SIK2; Phosphorylates IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB- specific coactivators, CRTC1-3 (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (798 aa) |
| | KLF15 | Kruppel like factor 15. (403 aa) |
| | KLF3 | Kruppel like factor 3. (347 aa) |
| | EGFR | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa) |
| | NCOR1 | Uncharacterized protein. (440 aa) |
| | PPARA | Uncharacterized protein. (468 aa) |
| | PTGDS | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (185 aa) |
| | SOAT1 | O-acyltransferase. (551 aa) |
| | ESRRG | Uncharacterized protein. (519 aa) |
| | SMARCD3 | SWIB domain-containing protein. (485 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (290 aa) |
| | FZD2 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] (557 aa) |
| | HMGCS1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (542 aa) |
| | COL3A1 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa) |
| | LDHB | L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (333 aa) |
| | KLF6 | KLF6. (283 aa) |
| | FASN | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2512 aa) |
| | RARA | Retinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning and appears to be required for skin development. Belongs to the nuclear hormone receptor family. NR1 subfamily. (460 aa) |
| | MLXIPL | BHLH domain-containing protein. (895 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (644 aa) |
| | CXCL12 | SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (167 aa) |
| | GGPS1 | Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (299 aa) |
| | SOX17 | Uncharacterized protein. (410 aa) |
| | SQLE | SE domain-containing protein. (573 aa) |
| | CEL | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (555 aa) |
| | ADIPOR2 | Uncharacterized protein. (386 aa) |
| | ATF6 | Activating transcription factor 6. (671 aa) |
| | ACACA | Acetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. (2355 aa) |
| | ST3GAL5 | Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (368 aa) |
| | FDPS | Farnesyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (354 aa) |
| | LCAT | Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and influences cerebral spinal [...] (594 aa) |
| | KLF9 | Kruppel like factor 9. (235 aa) |
| | CDKN2B | p15INK4b tumor suppressor. (139 aa) |
| | KLF13 | Kruppel like factor 13. (277 aa) |
| | FGF23 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa) |
| | SERTAD2 | SERTA domain-containing protein. (316 aa) |
| | GPX8 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa) |
| | LOC408038 | Keratin. (124 aa) |
| | MOGAT1 | Monoacylglycerol O-acyltransferase 1. (425 aa) |
| | IGFALS | Insulin like growth factor binding protein acid labile subunit. (589 aa) |
| | AGPAT2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (211 aa) |
| | FGB | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. (488 aa) |
| | RBP | Riboflavin-binding protein, yolk major form; Required for the transport of riboflavin to the developing oocyte; Belongs to the folate receptor family. (238 aa) |
| | JUN | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (310 aa) |
| | F11 | Coagulation factor XI; Belongs to the peptidase S1 family. (608 aa) |
| | VWF | Uncharacterized protein. (2800 aa) |
| | INSIG1 | Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (252 aa) |
| | PCF11 | PCF11 cleavage and polyadenylation factor subunit. (1690 aa) |
| | HADHB | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (474 aa) |
| | APOB | Apolipoprotein B; Apolipoprotein B is a major protein constituent of chylomicrons, VLDL and LDL. It functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. (4631 aa) |
| | KLF11 | Uncharacterized protein. (530 aa) |
| | GSTA3 | Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (221 aa) |
| | LOC396380 | Glutathione S-transferase 3; Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity. (229 aa) |
| | FBXO9 | F-box domain-containing protein. (435 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (295 aa) |
| | BMP5 | BMP5. (453 aa) |
| | NR0B1 | NR LBD domain-containing protein. (263 aa) |
| | PROS1 | Protein S. (702 aa) |
| | FOXO3 | Forkhead box O3. (660 aa) |
| | CDH2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa) |
| | ZBTB20 | Zinc finger and BTB domain containing 20. (669 aa) |
| | SPARC | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa) |
| | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa) |
| | DHCR7 | Uncharacterized protein. (474 aa) |
| | KLF2 | Kruppel-like factor 2. (380 aa) |
| | MFSD2A | Major facilitator superfamily domain containing 2A. (528 aa) |
| | MTOR | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa) |
| | E2F1 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa) |
| | AACS | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). (743 aa) |
| | BRCA1 | Uncharacterized protein. (1749 aa) |
| | SIRT1 | Deacetylase sirtuin-type domain-containing protein. (881 aa) |
| | PROC | Uncharacterized protein. (433 aa) |
| | E2F4 | E2F transcription factor 4. (414 aa) |
| | LAMB3 | Laminin subunit beta 3. (1168 aa) |
| | CETP | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). (505 aa) |
| | NR0B2 | NR LBD domain-containing protein. (262 aa) |
| | PER3 | PAS domain-containing protein. (1182 aa) |
| | IDH1 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa) |
| | FGA | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. (741 aa) |
| | FGG | Fibrinogen C-terminal domain-containing protein. (438 aa) |
| | MSMO1 | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (296 aa) |
| | LOC417800 | Uncharacterized protein. (225 aa) |
| | PDK4 | Protein-serine/threonine kinase. (414 aa) |
| | GSTZ1 | Uncharacterized protein; Belongs to the GST superfamily. (266 aa) |
| | PLPP3 | acidPPc domain-containing protein. (313 aa) |
| | EREG | EGF-like domain-containing protein. (153 aa) |
| | THRB | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine; Belongs to the nuclear hormone receptor family. NR1 subfamily. (476 aa) |
| | IGFBP2 | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (311 aa) |
| | NR1H4 | Farnesoid X receptor. (473 aa) |
| | MANBA | Mannosidase beta. (883 aa) |
| | PRL | Prolactin. (229 aa) |
| | SIRT5 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (309 aa) |
| | AKR1D1 | Aldo_ket_red domain-containing protein. (448 aa) |
| | PLAGL1 | PLAG1 like zinc finger 1. (776 aa) |
| | VNN1 | CN hydrolase domain-containing protein. (507 aa) |
| | FBLN1 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes; Belongs to the fibulin family. (704 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK. (671 aa) |
| | HMGCR | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (930 aa) |
| | GSTO2 | Uncharacterized protein. (239 aa) |
| | CASP8 | Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa) |
| | F2 | Uncharacterized protein; Belongs to the peptidase S1 family. (644 aa) |
| | HSPD1 | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] (573 aa) |
| | LAMB1 | Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1785 aa) |
| | EGR1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa) |
| | MASTL | Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser- 62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity hi [...] (889 aa) |
| | ACOX2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (675 aa) |
| | CPT1A | Carnitine palmitoyltransferase I; Belongs to the carnitine/choline acetyltransferase family. (770 aa) |
| | ACOT8 | Acyl-CoA thioesterase 8. (372 aa) |
| | IDI2 | Nudix hydrolase domain-containing protein. (282 aa) |
| | PEX11A | Peroxisomal biogenesis factor 11 alpha. (404 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | ADIPOQ | C1q domain-containing protein. (244 aa) |
| | SOX8 | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. (470 aa) |
| | SLC27A4 | Solute carrier family 27 member 4. (802 aa) |
| | GPX3 | Uncharacterized protein. (208 aa) |
| | LIPC | Lipase C, hepatic type. (419 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (651 aa) |
| | NR1H3 | Uncharacterized protein. (519 aa) |
| | TFPI | Tissue factor pathway inhibitor. (311 aa) |
| | PPARD | Uncharacterized protein. (545 aa) |
| | BTG2 | BTG anti-proliferation factor 2. (164 aa) |
| | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (726 aa) |
| | RORA | Uncharacterized protein. (524 aa) |
| | HMGCS2 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (517 aa) |
| | PROZ | Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (358 aa) |
| | COMT | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (262 aa) |
| | FBXL12 | Uncharacterized protein. (471 aa) |
| | CREM | Uncharacterized protein. (294 aa) |
| | STARD4 | START domain-containing protein. (224 aa) |
| | PNPLA3 | Patatin like phospholipase domain containing 3. (543 aa) |
| | NTRK2 | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] (842 aa) |
| | GARNL3 | GTPase-activating Rap/Ran-GAP domain-like protein 3; Belongs to the GARNL3 family. (994 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (494 aa) |
