(29 nodes) (2018) The induction and consequences of Influenza A virus-induced cell death. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	VDAC1	Uncharacterized protein. (307 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	DFNA5	Uncharacterized protein. (505 aa)
	IL22	Uncharacterized protein. (197 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	FADD	Fas associated via death domain. (195 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	NLRX1	NLR family member X1. (990 aa)
	BECN1	Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. (447 aa)
	RNF43	RING-type domain-containing protein. (825 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (486 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	RIPK3	Uncharacterized protein. (424 aa)
	API5	Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. (526 aa)
	IFNA3	Interferon. (193 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	CASP18	Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
	CD83	CD83 molecule. (215 aa)
	MCL1	Uncharacterized protein. (335 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	ANXA5	Annexin A5; Collagen-binding protein. (321 aa)
	BCL2L1	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
	SCRIB	Uncharacterized protein. (252 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA5	APAF1	ENSGALP00000055261	ENSGALP00000037437	Annexin A5; Collagen-binding protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.558
ANXA5	ATG5	ENSGALP00000055261	ENSGALP00000050539	Annexin A5; Collagen-binding protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.478
ANXA5	BCL2L1	ENSGALP00000055261	ENSGALP00000054103	Annexin A5; Collagen-binding protein.	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.759
ANXA5	BECN1	ENSGALP00000055261	ENSGALP00000004697	Annexin A5; Collagen-binding protein.	Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family.	0.498
ANXA5	CASP18	ENSGALP00000055261	ENSGALP00000065273	Annexin A5; Collagen-binding protein.	Initiator caspase; Belongs to the peptidase C14A family.	0.811
ANXA5	CASP3	ENSGALP00000055261	ENSGALP00000068843	Annexin A5; Collagen-binding protein.	Caspase-3; Belongs to the peptidase C14A family.	0.960
ANXA5	CASP8	ENSGALP00000055261	ENSGALP00000013591	Annexin A5; Collagen-binding protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.816
ANXA5	CD8A-2	ENSGALP00000055261	ENSGALP00000059832	Annexin A5; Collagen-binding protein.	Ig-like domain-containing protein.	0.785
ANXA5	CD8A-3	ENSGALP00000055261	ENSGALP00000071819	Annexin A5; Collagen-binding protein.	Ig-like domain-containing protein.	0.785
ANXA5	CYCS	ENSGALP00000055261	ENSGALP00000017934	Annexin A5; Collagen-binding protein.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.765
ANXA5	FADD	ENSGALP00000055261	ENSGALP00000012326	Annexin A5; Collagen-binding protein.	Fas associated via death domain.	0.535
ANXA5	IFNA3	ENSGALP00000055261	ENSGALP00000070204	Annexin A5; Collagen-binding protein.	Interferon.	0.499
ANXA5	IL1B	ENSGALP00000055261	ENSGALP00000050171	Annexin A5; Collagen-binding protein.	Interleukin-1; Belongs to the IL-1 family.	0.654
ANXA5	IL6	ENSGALP00000055261	ENSGALP00000068117	Annexin A5; Collagen-binding protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.682
ANXA5	MCL1	ENSGALP00000055261	ENSGALP00000062575	Annexin A5; Collagen-binding protein.	Uncharacterized protein.	0.639
ANXA5	TLR4	ENSGALP00000055261	ENSGALP00000011319	Annexin A5; Collagen-binding protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.486
APAF1	ANXA5	ENSGALP00000037437	ENSGALP00000055261	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Annexin A5; Collagen-binding protein.	0.558
APAF1	ATG5	ENSGALP00000037437	ENSGALP00000050539	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.435
APAF1	BCL2L1	ENSGALP00000037437	ENSGALP00000054103	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.962
APAF1	BECN1	ENSGALP00000037437	ENSGALP00000004697	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family.	0.431