(16 nodes) (2018) New Vaccine Technologies to Combat Outbreak Situations. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD86	Uncharacterized protein. (319 aa)
	IRF7	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
	IFIH1	Uncharacterized protein. (1102 aa)
	GLS2	ANK_REP_REGION domain-containing protein. (667 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	CD4	Uncharacterized protein. (487 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (221 aa)
	IFNA3	Interferon. (193 aa)
	ICOS	IGv domain-containing protein. (232 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	TBK1	Protein kinase domain-containing protein. (729 aa)
	EIF2AK2	Uncharacterized protein. (550 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	CD80	Uncharacterized protein. (316 aa)
	MX1	Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus. (705 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD80	ENSGALP00000065611	ENSGALP00000024911	Uncharacterized protein.	Uncharacterized protein.	0.983
CD4	CD86	ENSGALP00000065611	ENSGALP00000036384	Uncharacterized protein.	Uncharacterized protein.	0.983
CD4	CD8A-2	ENSGALP00000065611	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.984
CD4	CD8A-3	ENSGALP00000065611	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.982
CD4	EIF2AK2	ENSGALP00000065611	ENSGALP00000017163	Uncharacterized protein.	Uncharacterized protein.	0.438
CD4	ICOS	ENSGALP00000065611	ENSGALP00000073855	Uncharacterized protein.	IGv domain-containing protein.	0.922
CD4	IFIH1	ENSGALP00000065611	ENSGALP00000047949	Uncharacterized protein.	Uncharacterized protein.	0.582
CD4	IFNA3	ENSGALP00000065611	ENSGALP00000070204	Uncharacterized protein.	Interferon.	0.955
CD4	IRF7	ENSGALP00000065611	ENSGALP00000038233	Uncharacterized protein.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...]	0.724
CD4	MX1	ENSGALP00000065611	ENSGALP00000025952	Uncharacterized protein.	Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.	0.574
CD4	TBK1	ENSGALP00000065611	ENSGALP00000015982	Uncharacterized protein.	Protein kinase domain-containing protein.	0.496
CD4	TLR3	ENSGALP00000065611	ENSGALP00000021914	Uncharacterized protein.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.869
CD4	TLR7	ENSGALP00000065611	ENSGALP00000070844	Uncharacterized protein.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.897
CD80	CD4	ENSGALP00000024911	ENSGALP00000065611	Uncharacterized protein.	Uncharacterized protein.	0.983
CD80	CD86	ENSGALP00000024911	ENSGALP00000036384	Uncharacterized protein.	Uncharacterized protein.	0.992
CD80	CD8A-2	ENSGALP00000024911	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.959
CD80	CD8A-3	ENSGALP00000024911	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.959
CD80	ICOS	ENSGALP00000024911	ENSGALP00000073855	Uncharacterized protein.	IGv domain-containing protein.	0.923
CD80	IFNA3	ENSGALP00000024911	ENSGALP00000070204	Uncharacterized protein.	Interferon.	0.706
CD80	IRF7	ENSGALP00000024911	ENSGALP00000038233	Uncharacterized protein.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...]	0.554