node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE | ACTB | ENSGALP00000039731 | ENSGALP00000060844 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.596 |
ACE | GAPDH | ENSGALP00000039731 | ENSGALP00000063325 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | 0.404 |
ACTB | ACE | ENSGALP00000060844 | ENSGALP00000039731 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | 0.596 |
ACTB | GAPDH | ENSGALP00000060844 | ENSGALP00000063325 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | 0.988 |
AvBD1 | AvBD6 | ENSGALP00000035925 | ENSGALP00000026847 | Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. | Gallinacin-6; Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis. | 0.987 |
AvBD1 | AvBD7 | ENSGALP00000035925 | ENSGALP00000030905 | Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. | Gallinacin-7; Has bactericidal activity. | 0.977 |
AvBD1 | DEFB4A | ENSGALP00000035925 | ENSGALP00000030904 | Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. | Gallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. | 0.994 |
AvBD6 | AvBD1 | ENSGALP00000026847 | ENSGALP00000035925 | Gallinacin-6; Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis. | Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. | 0.987 |
AvBD6 | AvBD7 | ENSGALP00000026847 | ENSGALP00000030905 | Gallinacin-6; Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis. | Gallinacin-7; Has bactericidal activity. | 0.522 |
AvBD6 | DEFB4A | ENSGALP00000026847 | ENSGALP00000030904 | Gallinacin-6; Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis. | Gallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. | 0.986 |
AvBD7 | AvBD1 | ENSGALP00000030905 | ENSGALP00000035925 | Gallinacin-7; Has bactericidal activity. | Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. | 0.977 |
AvBD7 | AvBD6 | ENSGALP00000030905 | ENSGALP00000026847 | Gallinacin-7; Has bactericidal activity. | Gallinacin-6; Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis. | 0.522 |
AvBD7 | DEFB4A | ENSGALP00000030905 | ENSGALP00000030904 | Gallinacin-7; Has bactericidal activity. | Gallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. | 0.978 |
CYP17A1 | SQLE | ENSGALP00000032532 | ENSGALP00000044743 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. | SE domain-containing protein. | 0.416 |
DEFB4A | AvBD1 | ENSGALP00000030904 | ENSGALP00000035925 | Gallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. | Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. | 0.994 |
DEFB4A | AvBD6 | ENSGALP00000030904 | ENSGALP00000026847 | Gallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. | Gallinacin-6; Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis. | 0.986 |
DEFB4A | AvBD7 | ENSGALP00000030904 | ENSGALP00000030905 | Gallinacin-2; Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans. | Gallinacin-7; Has bactericidal activity. | 0.978 |
ELOVL2 | SQLE | ENSGALP00000071756 | ENSGALP00000044743 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] | SE domain-containing protein. | 0.572 |
GAPDH | ACE | ENSGALP00000063325 | ENSGALP00000039731 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. | 0.404 |
GAPDH | ACTB | ENSGALP00000063325 | ENSGALP00000060844 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.988 |