(11 nodes) (2018) Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome. network (Gallus gallus)

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Your Input:
	AICDA	CMP/dCMP-type deaminase domain-containing protein. (198 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	GLB1L2	Beta-galactosidase. (656 aa)
	CTCF	Transcriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene. (739 aa)
	GLB1	Beta-galactosidase. (652 aa)
	TDG	UDG domain-containing protein. (546 aa)
	SCAI	Suppressor of cancer cell invasion. (642 aa)
	GLB1L	Galactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family. (633 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (299 aa)
	SMUG1	Single-strand-selective monofunctional uracil-DNA glycosylase 1. (332 aa)
	IFNA3	Interferon. (193 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	GAPDH	ENSGALP00000023051	ENSGALP00000063325	CMP/dCMP-type deaminase domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.541
AICDA	SMUG1	ENSGALP00000023051	ENSGALP00000071202	CMP/dCMP-type deaminase domain-containing protein.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.637
AICDA	TDG	ENSGALP00000023051	ENSGALP00000045187	CMP/dCMP-type deaminase domain-containing protein.	UDG domain-containing protein.	0.695
AICDA	UNG	ENSGALP00000023051	ENSGALP00000033675	CMP/dCMP-type deaminase domain-containing protein.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.898
CTCF	GAPDH	ENSGALP00000058125	ENSGALP00000063325	Transcriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.508
GAPDH	AICDA	ENSGALP00000063325	ENSGALP00000023051	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	CMP/dCMP-type deaminase domain-containing protein.	0.541
GAPDH	CTCF	ENSGALP00000063325	ENSGALP00000058125	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	Transcriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene.	0.508
GAPDH	IFNA3	ENSGALP00000063325	ENSGALP00000070204	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	Interferon.	0.763
GAPDH	UNG	ENSGALP00000063325	ENSGALP00000033675	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.485
GLB1	GLB1L	ENSGALP00000057706	ENSGALP00000018459	Beta-galactosidase.	Galactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family.	0.902
GLB1L	GLB1	ENSGALP00000018459	ENSGALP00000057706	Galactosidase beta 1 like; Belongs to the glycosyl hydrolase 35 family.	Beta-galactosidase.	0.902
IFNA3	GAPDH	ENSGALP00000070204	ENSGALP00000063325	Interferon.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.763
SMUG1	AICDA	ENSGALP00000071202	ENSGALP00000023051	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	CMP/dCMP-type deaminase domain-containing protein.	0.637
SMUG1	TDG	ENSGALP00000071202	ENSGALP00000045187	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	UDG domain-containing protein.	0.971
SMUG1	UNG	ENSGALP00000071202	ENSGALP00000033675	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.929
TDG	AICDA	ENSGALP00000045187	ENSGALP00000023051	UDG domain-containing protein.	CMP/dCMP-type deaminase domain-containing protein.	0.695
TDG	SMUG1	ENSGALP00000045187	ENSGALP00000071202	UDG domain-containing protein.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.971
TDG	UNG	ENSGALP00000045187	ENSGALP00000033675	UDG domain-containing protein.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.885
UNG	AICDA	ENSGALP00000033675	ENSGALP00000023051	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	CMP/dCMP-type deaminase domain-containing protein.	0.898
UNG	GAPDH	ENSGALP00000033675	ENSGALP00000063325	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.485