(32 nodes) (2018) Acute microglia ablation induces neurodegeneration in the somatosensory system. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD3	Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa)
	CD86	Uncharacterized protein. (319 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	IFNA3	Interferon. (193 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
	CD4	Uncharacterized protein. (487 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	MOG	Ig-like domain-containing protein. (202 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	IFNAR1	Uncharacterized protein. (569 aa)
	TREM2	Ig-like domain-containing protein. (237 aa)
	CNP	Uncharacterized protein. (534 aa)
	STAT2	Signal transducer and activator of transcription. (961 aa)
	CCL5	C-C motif chemokine. (90 aa)
	IFIH1	Uncharacterized protein. (1102 aa)
	ABCA2	ATP binding cassette subfamily A member 2. (2509 aa)
	STAT1	Signal transducer and activator of transcription. (755 aa)
	FOXP1	Forkhead box protein P1; Transcriptional repressor. (686 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	IRF7	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (422 aa)
	OLFML3	Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). (392 aa)
	SETX	Senataxin. (2801 aa)
	TMEM119	Transmembrane protein 119. (245 aa)
	CSF1R	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
	USP41	Ubiquitin carboxyl-terminal hydrolase. (424 aa)
	CD80	Uncharacterized protein. (316 aa)
	MX1	Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus. (705 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CD4	ENSGALP00000039454	ENSGALP00000065611	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.712
B2M	CD80	ENSGALP00000039454	ENSGALP00000024911	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.584
B2M	CD8A-2	ENSGALP00000039454	ENSGALP00000059832	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.976
B2M	CD8A-3	ENSGALP00000039454	ENSGALP00000071819	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Ig-like domain-containing protein.	0.770
B2M	CSF1R	ENSGALP00000039454	ENSGALP00000009176	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.423
B2M	IFIH1	ENSGALP00000039454	ENSGALP00000047949	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.503
B2M	IFNA3	ENSGALP00000039454	ENSGALP00000070204	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Interferon.	0.473
B2M	PCNA	ENSGALP00000039454	ENSGALP00000064149	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.727
B2M	STAT1	ENSGALP00000039454	ENSGALP00000046362	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Signal transducer and activator of transcription.	0.467
BDNF	CASP3	ENSGALP00000071950	ENSGALP00000068843	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Caspase-3; Belongs to the peptidase C14A family.	0.740
BDNF	CSF1R	ENSGALP00000071950	ENSGALP00000009176	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.741
BDNF	CX3CR1	ENSGALP00000071950	ENSGALP00000057621	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.451
BDNF	GFAP	ENSGALP00000071950	ENSGALP00000001335	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.864
CASP1	CCL5	ENSGALP00000070056	ENSGALP00000049143	Uncharacterized protein; Belongs to the peptidase C14A family.	C-C motif chemokine.	0.491
CASP1	CD4	ENSGALP00000070056	ENSGALP00000065611	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.636
CASP1	CD86	ENSGALP00000070056	ENSGALP00000036384	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.438
CASP1	CD8A-2	ENSGALP00000070056	ENSGALP00000059832	Uncharacterized protein; Belongs to the peptidase C14A family.	Ig-like domain-containing protein.	0.635
CASP1	CD8A-3	ENSGALP00000070056	ENSGALP00000071819	Uncharacterized protein; Belongs to the peptidase C14A family.	Ig-like domain-containing protein.	0.634
CASP1	IFIH1	ENSGALP00000070056	ENSGALP00000047949	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.561
CASP1	IFNA3	ENSGALP00000070056	ENSGALP00000070204	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon.	0.703