STRINGSTRING
ZAP70 ZAP70 TRAF1 TRAF1 TNFRSF18 TNFRSF18 STAT3 STAT3 STAT5A STAT5A MTOR MTOR TRAF4 TRAF4 CD40LG CD40LG BCL6 BCL6 TFRC TFRC GRB2 GRB2 MAPK12 MAPK12 CTLA4 CTLA4 TBK1 TBK1 TRAF5 TRAF5 IFNG IFNG CYCS CYCS JAK1 JAK1 TGFBR2 TGFBR2 IL6ST IL6ST CD80 CD80 IL17A IL17A CD86 CD86 OVAL OVAL CD40 CD40 IL4 IL4 PTPN22 PTPN22 CXCR5 CXCR5 CCL19-2 CCL19-2 FOXP1 FOXP1 STAT1 STAT1 ICOSLG ICOSLG CCR7 CCR7 COL3A1 COL3A1 CHUK CHUK IL7 IL7 MAPK14 MAPK14 STAT2 STAT2 SMAD2Z SMAD2Z MAPK11 MAPK11 IL6R IL6R ICOS ICOS PIK3C3 PIK3C3 CD8A-3 CD8A-3 IL21R IL21R IFNA3 IFNA3 TRAF6 TRAF6 CCL19 CCL19 IL6 IL6 LOXL1 LOXL1 TRAF3 TRAF3 CD4 CD4 CXCL13 CXCL13 CD8A-2 CD8A-2 SMAD3 SMAD3 CSK CSK LCK LCK IL10 IL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZAP70Tyrosine-protein kinase. (609 aa)
TRAF1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TNFRSF18Uncharacterized protein. (258 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
TRAF4TNF receptor-associated factor. (470 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa)
BCL6B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily. (776 aa)
GRB2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa)
MAPK12Mitogen-activated protein kinase. (361 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (205 aa)
TBK1Protein kinase domain-containing protein. (729 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
JAK1Tyrosine-protein kinase. (1150 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (671 aa)
IL6STGlycoprotein 130. (918 aa)
CD80Uncharacterized protein. (316 aa)
IL17AUncharacterized protein. (169 aa)
CD86Uncharacterized protein. (319 aa)
OVALOvalbumin; Non-inhibitory serpin. Storage protein of egg white. (386 aa)
CD40Uncharacterized protein. (299 aa)
IL4Interleukin 4. (136 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (775 aa)
CXCR5Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (371 aa)
CCL19-2SCY domain-containing protein. (99 aa)
FOXP1Forkhead box protein P1; Transcriptional repressor. (686 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
ICOSLGICOS ligand. (296 aa)
CCR7C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa)
IL7Interleukin-7. (146 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
SMAD2ZMothers against decapentaplegic homolog. (467 aa)
MAPK11Mitogen-activated protein kinase. (360 aa)
IL6RUncharacterized protein. (445 aa)
ICOSIGv domain-containing protein. (232 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
IL21RUncharacterized protein. (616 aa)
IFNA3Interferon. (193 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
CCL19C-C motif chemokine. (108 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
LOXL1Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin; Belongs to the lysyl oxidase family. (511 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
CD4Uncharacterized protein. (487 aa)
CXCL13Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
SMAD3Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa)
CSKTyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs). Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma mem [...] (450 aa)
LCKProto-oncogene tyrosine-protein kinase LCK; Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity); Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. (508 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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